Data · dataset · 2025
Hypervirulent Klebsiella Pneumonia induces Liver Abscess by promoting Neutrophil Extracellular Trap Formation through Activating NLRP3 Inflammasome
Listed in ScienceDB
Hypervirulent Klebsiella pneumoniae (hvKP) has spread globally since first described in the Asian Pacific Rim.
Description
Neutrophil extracellular trap formation (NETosis) is a crucial anti-infection mechanism of neutrophils. However, the role of hvKP pathogenicity on neutrophil extracellular trap formation remains unclear.
Here we show the influence of hvKP strain NTUH-K2044 on NETosis and related mechanisms. We investigate that hvKP significantly lead to liver abscess and a large number of neutrophils infiltration in liver tissues from murine models and had hypermucoviscosity by carried rmpA gene. hvKP enhanced the protein levels of MPO and promoted the chromatin depolymerization of human peripheral blood neutrophils compared with classic Klebsiella pneumonia (cKP) strain HS11286.
Read the rest (2 more)
In addition, hvKP markedly promoted the ROS and cytokines levels in neutrophils. Moreover, hvKP significantly accelerated the activation of NLRP3 inflammatory and the production of NETosis compared with cKP in neutrophils. Therefore, hvKP has a stronger ability to resist neutrophil killing and promote the activation of NLRP3 inflammatory and induce NETosis.
Our findings provide a novel mechanism underlying of hvKP innate immune evasion
Links
Where it is published
- DOI doi.org/10.57760/sciencedb.34045 ↗
DOI / persistent id · from scidb cn
Catalogue records · 1
- OAI-PMH record scidb.cn/oai?verb=GetRecord&metadataPrefix=oai_dc&identifier=10.57760%2… ↗
metadata API · from scidb cn
Topics
- From keywords
- Earth & Environmental Science · Engineering · Humanities · Life Sciences · Social Science
Provenance · 1 source records, 10 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| ScienceDB | 10.57760/sciencedb.34045 | 11 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · scidb cn | connector:scidb_cn@1.0.0 | |
| concepts[field].local:field:earth-environmental | mapping · scidb cn | connector:scidb_cn@1.0.0 | |
| concepts[field].local:field:engineering | mapping · scidb cn | connector:scidb_cn@1.0.0 | |
| concepts[field].local:field:humanities | mapping · scidb cn | connector:scidb_cn@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · scidb cn | connector:scidb_cn@1.0.0 | |
| concepts[field].local:field:social-science | mapping · scidb cn | connector:scidb_cn@1.0.0 | |
| description | source · scidb cn | connector:scidb_cn@1.0.0 | /metadata/dc/description |
| license | source · scidb cn | connector:scidb_cn@1.0.0 | /metadata/dc/rights |
| publication_date | source · scidb cn | connector:scidb_cn@1.0.0 | |
| title | source · scidb cn | connector:scidb_cn@1.0.0 | /metadata/dc/title |