Serum pemphigoid antibodies in 76 patients: ocular and other sites compared

This was calculated using data from Wieland CN et al. [Wieland CN, Comfere NI, Gibson LE, et al. Anti-bullous pemphigoid 180 and 230 antibodies in a sample of unaffected subjects. Arch Dermatol 2010;146(1):21-5] on age, sex stratified controls having detectable levels of these in 14/337 (4.15%), and our pilot data in our MMP cases in which 8/32 (25%) had detectable levels. Seventy-six MMP patients were prospectively phenotyped using a data collection tool and matched with 45 healthy age sex matched controls.

All patients and controls had serum collected and this was tested for the presence of pemphigoid serum autoantibodies using a panel of 5 tests. The sensitivity and specificity of autoantibody detection, Youden’s index, and significant differences, compared to controls, for individual tests and test combinations were evaluated.