Respiratory Syncytial Virus genotype BA in Kilifi, Kenya : evolutionary dynamics, 15 years on

In addition, there was consistent seasonal fluctuations in relative genetic diversity. Amino acid changes increasingly accumulated over the surveillance period including two residues (N178S and Q180R) that mapped to monoclonal antibody 2D10 epitopes, as well as addition of putative N-glycosylation sequons. Further, switching and toggling of amino acids within and between epidemics was observed.

On a global phylogeny, the BA viruses from different countries form geographically isolated clusters suggesting substantial localized variants. This study offers insights into longitudinal population dynamics of a globally endemic RSV genotype within a discrete location.<br><br>Data record consists of raw data in tabular and R format, accompanied by a data dictionary and a README file. This study is part of a longitudinal surveillance study established to understand the epidemiology and disease burden of RSV associated pneumonia admissions to Kilifi County Hospital (KCH).

Fields available in the data include month and year of sample collection, Eligibles (Under fives with severe or very severe pneumonia), RSVA and RSVB positives, proportion tested, and FUBAR all sequences output. The Kilifi G gene sequences presented in the related publication are available in GenBank (accession numbers KP862065-KP862529, KX775722-KX775849 and MH742792-MH742925).