Data · dataset · 2026
<p>A <i>nhre3</i> homozygous mutant of rare minnow exhibits resistance to GCRV.</p>
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<p>(A) Mutation type in the homozygous <i>nhre3</i> knockout mutant of rare minnow.
Description
Compared with the wild type, the mutant harbors a 12 bp deletion and a 13 bp insertion within exon 6. (B) Total RNA was extracted from wild-type and mutant larvae, and the expression level of <i>nhre3</i> was assessed using qPCR.
Expression of <i>nhre3</i> in the mutant was significantly reduced compared with that in the wild type. (C) Survival curves of larvae following viral challenge. Mutant larvae exhibited prolonged survival and a reduced mortality rate compared with those in the wild type.
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(D) Survival curves of adult fish following viral challenge. Mutant adults exhibited prolonged survival and a reduced mortality rate compared with those in the wild type. All experiments were repeated for at least three times with similar results.
(E) Expression levels of the GCRV S4 and S11 segments in liver tissue from wild-type and mutant strains on day 4 after infection. (F) Expression levels of the GCRV S4 and S11 segments in liver tissue from wild-type and mutant strains on day 7 after infection.</p>
Links
Where it is published
- DOI doi.org/10.1371/journal.ppat.1014544.g002 ↗
DOI / persistent id · from zivahub uct ac za
Catalogue records · 1
- OAI-PMH record api.figshare.com/v2/oai?verb=GetRecord&metadataPrefix=oai_dc&identifier=oai%3Af… ↗
metadata API · from zivahub uct ac za
Topics
Provenance · 1 source records, 17 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| ZivaHub | oai:figshare.com:article/34026289 | 8 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | |
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| concepts[field].anzsrc:field:320211 | mapping · zivahub uct ac za | vocabulary-mapper@1.0.0 | keywords['Infectious Diseases'] |
| concepts[field].anzsrc:field:440710 | mapping · zivahub uct ac za | vocabulary-mapper@1.0.0 | keywords['Science Policy'] |
| concepts[field].anzsrc:group:3103 | mapping · zivahub uct ac za | vocabulary-mapper@1.0.0 | keywords['Ecology'] |
| concepts[field].anzsrc:group:3105 | mapping · zivahub uct ac za | vocabulary-mapper@1.0.0 | keywords['Genetics'] |
| concepts[field].anzsrc:group:3107 | mapping · zivahub uct ac za | vocabulary-mapper@1.0.0 | keywords['Microbiology'] |
| concepts[field].anzsrc:group:3108 | mapping · zivahub uct ac za | vocabulary-mapper@1.0.0 | keywords['Plant Biology'] |
| concepts[field].anzsrc:group:3204 | mapping · zivahub uct ac za | vocabulary-mapper@1.0.0 | keywords['Immunology'] |
| concepts[field].local:field:earth-environmental | mapping · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | |
| concepts[field].local:field:medicine-health | mapping · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | |
| concepts[field].local:field:psychology-behavioral | mapping · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | |
| description | source · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | /metadata/dc/description |
| license | source · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | /metadata/dc/rights |
| publication_date | source · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | |
| title | source · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | /metadata/dc/title |