Data · dataset · 2025
RNA-Seq transcriptome profiling of soleus from adult and aged mice following disuse muscle atrophy and recovery
Listed in NASA Data Portal
Rodent hind limb unloading was used as a model for reduced muscle activity and eventual atrophy.
Description
After a 10 day period of unloading mice in this study were xe2 x80 x9creloaded xe2 x80 x9d for 3 days and regained use of their hind limbs. We report the application of Next-generation sequencing (NGS) technology for high-throughput profiling of mRNA in soleus muscle of adult (6 mo) and aged (22-24 mo) mice.
Our goal was to determine the effects of hind limb unloading and reloading on mRNA profiles in soleus muscle and compare between adult and aged mice. We find that there are distinct response in the profile of fatty acid oxidation TCA cycle ETC oxidative phosphorylation gene expression patterns in response to unloading and reloading. The repsonses are generally simialr between young and old mice.
Links
Get the data
- genelab-data.ndc.nasa.gov /genelab/accession/GLDS-295 ↗
RNA-Seq transcriptome profiling of soleus from adult and aged mice following disuse muscle atrophy and recovery
download · from data nasa gov
Where it is published
- NASA Data Portal dataset page data.nasa.gov/dataset/rna-seq-transcriptome-profiling-of-soleus-from-adult-a… ↗
landing page · from data nasa gov
Catalogue records · 1
- CKAN API data.nasa.gov/api/3/action/package_show?id=ebe23bad-b27b-4a75-af22-f953e31e1… ↗
metadata API · from data nasa gov
Topics
- From keywords
- Engineering
- Inferred from text
- RNA sequencing 65% · Sequencing 75%
Provenance · 1 source records, 9 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NASA Data Portal | ebe23bad-b27b-4a75-af22-f953e31e143a | 12 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| concepts[field].local:field:engineering | mapping · data nasa gov | connector:data_nasa_gov@1.0.0 | |
| concepts[modality].local:modality:rna-seq | enrichment · data nasa gov | keyword-concept-rules@1.0.0 | title+description (65%) |
| concepts[modality].local:modality:sequencing | enrichment · data nasa gov | keyword-concept-rules@1.0.0 | title+description (75%) |
| created_date | source · data nasa gov | connector:data_nasa_gov@1.0.0 | |
| description | source · data nasa gov | connector:data_nasa_gov@1.0.0 | /notes |
| license_text | source · data nasa gov | connector:data_nasa_gov@1.0.0 | |
| publication_date | source · data nasa gov | connector:data_nasa_gov@1.0.0 | |
| title | source · data nasa gov | connector:data_nasa_gov@1.0.0 | /title |
| updated_date | source · data nasa gov | connector:data_nasa_gov@1.0.0 |