Data · dataset · 2022
OCT6 inhibits the differentiation of porcine induced pluripotent stem cells through MAPK and PI3K signal regulations
Listed in ScienceDB
As a transcription factor of the POU family, OCT6 plays different roles in stem cell development and differentiation, but its role in porcine induced pluripotent stem cells (piPSCs) is unclear.
Description
Here we explored the function of OCT6 in piPSCs. We found that piPSCs overexpressing OCT6 could maintain clonal morphology and pluripotency in differentiation condition, with a similar gene expression pattern to that of non-differentiated piPSCs.
Functional analysis revealed that OCT6 alleviates the adverse effect on piPSC pluripotency caused by the inhibition of ERK signaling pathway, through activating PI3K-AKT signal activity. Our research shed new light on the mechanism for OCT6 promoted pluripotent stem cell maintenance.
Links
Where it is published
- DOI doi.org/10.57760/sciencedb.j00139.00029 ↗
DOI / persistent id · from scidb cn
Catalogue records · 1
- OAI-PMH record scidb.cn/oai?verb=GetRecord&metadataPrefix=oai_dc&identifier=10.57760%2… ↗
metadata API · from scidb cn
Topics
- From keywords
- Earth & Environmental Science · Engineering · Humanities · Life Sciences · Social Science
Provenance · 1 source records, 10 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| ScienceDB | 10.57760/sciencedb.j00139.00029 | 11 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · scidb cn | connector:scidb_cn@1.0.0 | |
| concepts[field].local:field:earth-environmental | mapping · scidb cn | connector:scidb_cn@1.0.0 | |
| concepts[field].local:field:engineering | mapping · scidb cn | connector:scidb_cn@1.0.0 | |
| concepts[field].local:field:humanities | mapping · scidb cn | connector:scidb_cn@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · scidb cn | connector:scidb_cn@1.0.0 | |
| concepts[field].local:field:social-science | mapping · scidb cn | connector:scidb_cn@1.0.0 | |
| description | source · scidb cn | connector:scidb_cn@1.0.0 | /metadata/dc/description |
| license | source · scidb cn | connector:scidb_cn@1.0.0 | /metadata/dc/rights |
| publication_date | source · scidb cn | connector:scidb_cn@1.0.0 | |
| title | source · scidb cn | connector:scidb_cn@1.0.0 | /metadata/dc/title |