Data Sheet 2_Ciprofol versus propofol for painless gastrointestinal endoscopy: a dose-stratified systematic review and meta-analysis.docx

Induction time and physician and patient satisfaction did not differ significantly. Ciprofol was associated with fewer reported episodes of hypotension (RR 0.81, 95% CI 0.72–0.90), injection pain (RR 0.13, 95% CI 0.08–0.22), respiratory depression (RR 0.47, 95% CI 0.27–0.83), and hypoxemia (RR 0.64, 95% CI 0.42–0.96).</p>Conclusion<p>Ciprofol and propofol produced broadly comparable procedural outcomes. The apparent advantages for selected adverse events and the dose-related recovery pattern are uncertain because all trials were conducted in China, several pooled outcomes were highly heterogeneous, outcome definitions varied, and publication bias was possible.

The dose-stratified findings are exploratory, and the results are hypothesis-generating and require confirmation in larger international trials.</p>Systematic Review Registration<p>crd.york.ac.uk/PROSPERO/view/CRD420251088249, identifier PROSPERO CRD420251088249.</p>