Data · dataset · 2025
Gene-expression profiling of Saccharomyces cerevisiae irradiated by high-LET radiations
Listed in NASA Data Portal
Ionizing radiations are categorized by linear energy transfer (LET) into low-LET and high-LET.
Description
High-LET is considered to have a higher relative biological effectiveness (RBE) than low-LET radiations. However the details of the effects have not been clearly determined.
The aim of this study was to characterize the difference between high-LET and low LET radiations. The global effects of the three types of high-LET radiations (fast neutron heavy ion (C) and thermal neutron) were compared with the low-LET radiation (gamma ray) using yeast DNA microarrays. Highly induced genes by the three types of high-LET radiations were those genes related to oxidative stress.
Read the rest (3 more)
Oxidative stress was one of the common factors associated with the four types of radiations. Oxidative stress induced by high-LET radiations may be more serious than that induced by gamma rays. Additionally genes related to protein synthesis and the ubiquitin and proteasome system were detected.
This suggests that more protein damages can be induced by high-LET radiation that denatures the proteins in yeast cells. The genes specifically altered by each type of high-LET radiation were also studied. Overall design: This series contains 4 kinds of irradiation-induced gene expression profiles.
Triplicates hybridization was done in each irradiation exposure and each array have high and low power scanned data respectively. All biological samples were collected independently.
Links
Get the data
- genelab-data.ndc.nasa.gov /genelab/accession/GLDS-97 ↗
Gene-expression profiling of Saccharomyces cerevisiae irradiated by high-LET radiations
download · from data nasa gov
Where it is published
- NASA Data Portal dataset page data.nasa.gov/dataset/gene-expression-profiling-of-saccharomyces-cerevisiae-… ↗
landing page · from data nasa gov
Catalogue records · 1
- CKAN API data.nasa.gov/api/3/action/package_show?id=38fd3383-688d-40a2-a7bb-aea28536a… ↗
metadata API · from data nasa gov
Related
Provenance · 1 source records, 6 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NASA Data Portal | 38fd3383-688d-40a2-a7bb-aea28536ac83 | 9 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| created_date | source · data nasa gov | connector:data_nasa_gov@1.0.0 | |
| description | source · data nasa gov | connector:data_nasa_gov@1.0.0 | /notes |
| license_text | source · data nasa gov | connector:data_nasa_gov@1.0.0 | |
| publication_date | source · data nasa gov | connector:data_nasa_gov@1.0.0 | |
| title | source · data nasa gov | connector:data_nasa_gov@1.0.0 | /title |
| updated_date | source · data nasa gov | connector:data_nasa_gov@1.0.0 |