<p>AlphaFold prediction and cellular validation of the interaction between TET2 and Vpr.</p>

Error bars represent the standard deviation (SD). <i>n.s.</i>, not statistically significant (<i>P</i> > 0.05); *, <i>P</i> < 0.05. (<b>D</b>) Functional validation of the Vpr C-terminal mutant in TET2 degradation. Western blot analysis showing that the Vpr C-terminal R88A mutant maintains its capacity to degrade TET2.

Western blots were performed in three independent biological replicates (<i>n</i> = 3) with one representative blot shown. (<b>E</b>) Statistical quantification of biological replicates. Densitometric quantification derived from the three independent experimental repeats.

Data are presented as mean. Error bars represent the standard deviation (SD). <i>n.s.</i>, not statistically significant (<i>P</i> > 0.05); *, <i>P</i> < 0.05; ***, <i>P</i> < 0.001.</p> <p>(TIF)</p>