Data · dataset · 2026
Investigating the impact of sacubitril/valsartan on cardiac structure, function, and remodelling in the diabetic heart
Listed in ZivaHub and Deakin Research Online and DMU Figshare — shown once because both records carry DOI 10.17034/32640246.v1
Diabetic cardiomyopathy (DbCM), a pre-heart failure (HF) stage, is recognised as a key intermediate stage and determinant for the future development of HF.
Description
To date, there are limited therapeutic options for DbCM. Sacubitril/valsartan, an angiotensin receptor neprilysin inhibitor (ARNI), may have therapeutic potential to improve diabetes-induced cardiac abnormalities.
This thesis studied the progression pattern of DbCM and potential benefits of sacubitril/valsartan. Plasma neprilysin activity was positively correlated with worsening cardiac function and structure. Sacubitril/valsartan could offer potential therapeutic benefits for preventing DbCM progression by modulating inflammatory responses via modulating interferon regulatory factor 7 (Irf7), thereby improving pro-fibrotic signalling.
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Furthermore, elevated B cell receptor-associated protein 31 (BAP31) in diabetic patients with pre-HFpEF receiving sacubitril/valsartan may mitigate the pathogenesis of DbCM. In summary, this thesis provides a signature of progression of DbCM and reveals a key driver in DbCM development. Sacubitril/valsartan may serve as therapeutic options in the context of preventing DbCM progression.<br><br><i>Thesis is embargoed until 31st December 2029</i>.<br><br><br>
Links
Where it is published
- DOI doi.org/10.17034/32640246.v1 ↗
DOI / persistent id · from zivahub uct ac za
Catalogue records · 1
- OAI-PMH record api.figshare.com/v2/oai?verb=GetRecord&metadataPrefix=oai_dc&identifier=oai%3Af… ↗
metadata API · from zivahub uct ac za
Topics
- From keywords
- Cardiomyopathy · Cardiomyopathy · Cardiomyopathy · Earth & Environmental Science · Earth & Environmental Science · Earth & Environmental Science
- Inferred from text
- Heart 75%
Provenance · 3 source records, 12 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| ZivaHub | oai:figshare.com:article/32640246 | 8 d ago | JSON v1 |
| Deakin Research Online | oai:figshare.com:article/32640246 | 8 d ago | JSON v1 |
| DMU Figshare | oai:figshare.com:article/32640246 | 8 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | |
| concepts[anatomy].local:anatomy:heart | enrichment · zivahub uct ac za | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[disease].local:disease:cardiomyopathy | mapping · zivahub uct ac za | vocabulary-mapper@1.0.0 | keywords['cardiomyopathy'] |
| concepts[disease].local:disease:cardiomyopathy | mapping · dro deakin edu au | vocabulary-mapper@1.0.0 | keywords['cardiomyopathy'] |
| concepts[disease].local:disease:cardiomyopathy | mapping · figshare dmu ac uk | vocabulary-mapper@1.0.0 | keywords['cardiomyopathy'] |
| concepts[field].local:field:earth-environmental | mapping · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | |
| concepts[field].local:field:earth-environmental | mapping · figshare dmu ac uk | connector:figshare_dmu_ac_uk@1.0.0 | |
| concepts[field].local:field:earth-environmental | mapping · dro deakin edu au | connector:dro_deakin_edu_au@1.0.0 | |
| description | source · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | /metadata/dc/description |
| license_text | source · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | |
| publication_date | source · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | |
| title | source · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | /metadata/dc/title |