Omics · study · 2026
ChIP-seq analysis of rat pancreatic cells treated with IL-1beta
Listed in NCBI GEO
Autoimmune diseases such as Type 1 Diabetes are characterized by overactive inflammatory signaling pathways.
Description
This study investigates how the pro-inflammatory cytokine interleukin-1-beta (IL-1beta) elicits changed gene expression in pancreatic beta-cells. Here we profile genomic DNA binding of transcription factor p65/RelA and RNA Polymerase II in response to IL-1beta in 832/13 cells.
This cell line is derived from INS-1 cells, a pancreatic insulinoma model for insulin-secreting beta-cells.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE308nnn/GSE308922 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE308922 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1333405 ncbi.nlm.nih.gov/bioproject/PRJNA1333405 ↗
project · from NCBI GEO
- PubMed 42572286 pubmed.ncbi.nlm.nih.gov/42572286 ↗
publication · from NCBI GEO
Topics
- Stated by source
- Genome binding/occupancy profiling by high throughput sequencing · Rattus norvegicus
- From keywords
- Life Sciences
Provenance · 1 source records, 7 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE308922 | 14 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:genome-binding-occupancy-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[organism].NCBITaxon:10116 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |