Defect-engineered amorphous-like nanointerceptors for T<sub>2</sub> MRI-Guided treatment of reperfusion injury

Herein, we report a defect-engineered amorphous-like MnCeOx nanointerceptor with dual capabilities of magnetic resonance imaging (MRI) -guided stroke diagnosis and ROS-scavenging therapy.

The synergistic effect of the amorphous-like structure and Mn-Ce solid solution induces abundant oxygen vacancies and a disordered surface, significantly boosting ROS catalytic removal. Theoretical calculations confirm that Mn doping and oxygen vacancy formation modulate the electronic structure, reduce the adsorption energy of ROS intermediates, and lower catalytic energy barriers, thereby enhancing enzyme-like activity.