Data · dataset · 2026
Labeling of DOTA and DOTA-Substance P with bismuth radioisotopes in solution and cross-linked dextran medium
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The labeling of H4DOTA (1,4,7,10-tetraazacyclododecane-N,N',N'',N'''-tetracetic acid) and H4DOTA-substance P with 207Bi in a cross-linked dextran medium and an aqueous solution was compared.
Description
The thermodynamic and kinetic parameters for DOTA complexation with Bi³⁺ were determined, and the apparent stability constant of 29.3 ± 0.4, obtained by the competitive sorption method, was consistent with literature data.
It was demonstrated that cross-linked dextran could be used as a suitable medium for determining stability constants for Bi³⁺ complexes. The stability of the 207Bi-DOTA complex formed at different temperatures was monitored over time in the presence of excess EDTA using UV spectrophotometry.A method for producing a labeled bioconjugate, 213Bi-DOTA-substance P, using a 225Ac/213Bi generator-synthesis module was developed.
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The presence of the cross-linked dextran medium did not affect the kinetics of radiolabeling, although the yield of the labeled bioconjugate slightly decreased (from 92% to 85%). In vitro stability of the bioconjugate obtained in the dextran medium is identical to that synthesized in solution. The radiopharmaceutical can be obtained with high radiochemical purity (>98%), eliminating the need for additional purification steps and reducing synthesis time.
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Where it is published
- DOI doi.org/10.57760/sciencedb.0108u ↗
DOI / persistent id · from scidb cn
Catalogue records · 1
- OAI-PMH record scidb.cn/oai?verb=GetRecord&metadataPrefix=oai_dc&identifier=10.57760%2… ↗
metadata API · from scidb cn
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- Earth & Environmental Science · Engineering · Humanities · Life Sciences · Social Science
Provenance · 1 source records, 10 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| ScienceDB | 10.57760/sciencedb.0108u | 12 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · scidb cn | connector:scidb_cn@1.0.0 | |
| concepts[field].local:field:earth-environmental | mapping · scidb cn | connector:scidb_cn@1.0.0 | |
| concepts[field].local:field:engineering | mapping · scidb cn | connector:scidb_cn@1.0.0 | |
| concepts[field].local:field:humanities | mapping · scidb cn | connector:scidb_cn@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · scidb cn | connector:scidb_cn@1.0.0 | |
| concepts[field].local:field:social-science | mapping · scidb cn | connector:scidb_cn@1.0.0 | |
| description | source · scidb cn | connector:scidb_cn@1.0.0 | /metadata/dc/description |
| license | source · scidb cn | connector:scidb_cn@1.0.0 | /metadata/dc/rights |
| publication_date | source · scidb cn | connector:scidb_cn@1.0.0 | |
| title | source · scidb cn | connector:scidb_cn@1.0.0 | /metadata/dc/title |