FiltDeTox classification of toxin candidates in the paired-end transcriptome of the false black coral Savalia savaglia

Starting from DeTox results, FiltDeTox combines DeTox flags (Rating), secretion predictions (WoLFPSort), HMMER-based mapping to VenomZone toxin families, Pfam toxin domains and toxin-related keywords to classify each ORF into four categories: Toxins-Candidates, Unlikely-Toxins, SCRs-WA (secreted cysteine-rich sequences with weak/absent annotation) and Non-Toxins.

The dataset provides: • Full_Classified_Data.tsv: complete table with all DeTox ORFs, annotations and the FiltDeTox_Classification column. • Four per-class tables (Toxins_Candidates.tsv, Unlikely_Toxins.tsv, SCRs_WA.tsv, Non_Toxins.tsv) plus FiltDeTox_Stats.tsv summarising ORF counts per class. • Per-class mature and precursor FASTA files (…_mature.fasta and …_precursor.fasta) for all four categories. • Per-class “full-length” TSVs (…_full-length.tsv), precursor FASTA files restricted to complete sequences (…_precursor_full-length-seqs.fasta) and small stats files (…_full-length_stats.txt). • Pfam_Domain_Summary_with_ORFs_Genes.tsv: domain-wise summary for Toxins-Candidates, including numbers of ORFs/transcripts/genes, total TPM and associated IDs. • Plot files (PNG and PDF): stacked barplots for FiltDeTox classes and DeTox flags, nested pie charts combining classes and flags, a pie chart of flags within Toxins-Candidates, and a combined dendrogram + dot plot of Pfam domains and their ORF/TPM profiles.