Data · dataset · 2021
cginess_and_aging
Listed in Teesside University Research Data Repository
Cellular aging is characterized by disruption of the nuclear lamina and its associated heterochromatin.
Description
How these structural changes within the nucleus contribute to age-related degeneration of the organism is unclear. Genes lacking CpG islands (CGI- genes) associate with nuclear lamina-associated heterochromatin when they are inactive.
Here, we show that the expression of these genes is globally activated in aged cells and tissues. This CGI- gene misexpression is a common feature of normal and pathological aging in mice and humans. We report evidence that CGI- gene upregulation is directly responsible for age-related physiological deterioration, notably for increased secretion of inflammatory mediators.
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These files are uncropped western blot images and unprocessed confocal microscopy images for this study. Each directory indicates a panel of the processed figures shown in the paper. Minimal image processing was applied prior to image analysis.
For microscopy, brightness and contrast were adjusted identically for compared image sets, and signal intensity was quantified using ImageJ Fiji 1.53c. See the paper for more details.
Links
Where it is published
- DOI doi.org/10.17632/n5fdym7wcw.1 ↗
DOI / persistent id · from researchdata tees ac uk
Catalogue records · 1
- OAI-PMH record data.mendeley.com/oai?verb=GetRecord&metadataPrefix=oai_dc&identifier=oai%3Adata… ↗
metadata API · from researchdata tees ac uk
Topics
- From keywords
- Earth & Environmental Science
- Inferred from text
- Image 75% · Microscopy 75%
Provenance · 1 source records, 8 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| Teesside University Research Data Repository | oai:data.mendeley.com/n5fdym7wcw.1 | 18 h ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · researchdata tees ac uk | connector:researchdata_tees_ac_uk@1.0.0 | |
| concepts[field].local:field:earth-environmental | mapping · researchdata tees ac uk | connector:researchdata_tees_ac_uk@1.0.0 | |
| concepts[modality].local:modality:image | enrichment · researchdata tees ac uk | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[modality].local:modality:microscopy | enrichment · researchdata tees ac uk | keyword-concept-rules@1.0.0 | title+description (75%) |
| description | source · researchdata tees ac uk | connector:researchdata_tees_ac_uk@1.0.0 | /metadata/dc/description |
| license | source · researchdata tees ac uk | connector:researchdata_tees_ac_uk@1.0.0 | /metadata/dc/rights |
| publication_date | source · researchdata tees ac uk | connector:researchdata_tees_ac_uk@1.0.0 | |
| title | source · researchdata tees ac uk | connector:researchdata_tees_ac_uk@1.0.0 | /metadata/dc/title |