The antifungal metabolites obtained from the rhizospheric Aspergillus sp. YIM PH30001 against pathogenic fungi of Panax notoginseng

Eight anthraquinones ( 1–8 ), three xanthones ( 11–13 ) and two phenols ( 9–10 ) were isolated from Aspergillus sp. associated with Panax notoginseng , and their structures were determined as ziganein-1-methyl ether ( 1 ), 8- O -methylchrysophanol (2 ), averythrin ( 3 ), averufin ( 4 ), 8- O -methyl averufin ( 5 ), versicolorin B ( 6 ), averantin ( 7 ), methyl-averantin ( 8 ), arugosin C ( 9 ), diorcinol ( 10 ), sterigmatocystin ( 11 ), demethylsterigmatocystin ( 12 ) and dihydrosterigmatocystin ( 13 ) by spectroscopic analyses.

Compounds 1 , 2 and 5 were the novel isolates from genus Aspergillus . Compounds 3 , 6 and 7 exhibited antifungal activity against Fusarium solani , pathogenic fungus of P. notoginseng , with minimum inhibitory concentrations (MICs) of 16 – 32 μg/mL, and compounds 1 , 3 , 4 , 7 and 9 showed antibacterial activity against Bacillus subtilis with MICs of 64–128 μg/mL, 16–32 μg/mL, 8–16 μg/mL, 16–32 μg/mL and 64–128 μg/mL, respectively.