Data · dataset · 2025
International Space Station conditions alter genomics proteomics and metabolomics in Aspergillus nidulans
Listed in Open NASA
The first global genomic proteomic and secondary metabolomic characterization of the filamentous fungus Aspergillus nidulans following growth onboard the International Space Station (ISS) is reported.
Description
The investigation included the A. nidulans wild-type and three mutant strains two of which were genetically engineered to enhance secondary metabolite production. Whole genome sequencing revealed that ISS conditions altered the A. nidulans genome in specific regions.
In strain CW12001 which features overexpression of the secondary metabolite global regulator laeA ISS conditions induced the loss of the laeA stop codon. Differential expression of proteins involved in stress response carbohydrate metabolic processes and secondary metabolite biosynthesis was also observed. ISS conditions significantly decreased prenyl xanthone production in the wild-type strain and increased asperthecin production in LO1362 and CW12001 which are deficient in a major DNA repair mechanism.
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These data provide valuable insights into the adaptation mechanism of A. nidulans to spacecraft environments.
Links
Get the data
- genelab-data.ndc.nasa.gov /genelab/accession/GLDS-233 ↗
International Space Station conditions alter genomics proteomics and metabolomics in Aspergillus nidulans
download · from open nasa gov
Where it is published
- Open NASA dataset page data.nasa.gov/dataset/international-space-station-conditions-alter-genomics-… ↗
landing page · from open nasa gov
Catalogue records · 1
- CKAN API data.nasa.gov/api/3/action/package_show?id=1b6134e3-b856-4e94-baed-43c1ee94d… ↗
metadata API · from open nasa gov
Topics
- From keywords
- Engineering
- Inferred from text
- Genome sequencing 75% · Mass spectrometry 65% · Sequencing 75%
Related
Provenance · 1 source records, 10 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| Open NASA | 1b6134e3-b856-4e94-baed-43c1ee94d7ef | 16 h ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| concepts[field].local:field:engineering | mapping · open nasa gov | connector:open_nasa_gov@1.0.0 | |
| concepts[modality].local:modality:genome-sequencing | enrichment · open nasa gov | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[modality].local:modality:mass-spectrometry | enrichment · open nasa gov | keyword-concept-rules@1.0.0 | title+description (65%) |
| concepts[modality].local:modality:sequencing | enrichment · open nasa gov | keyword-concept-rules@1.0.0 | title+description (75%) |
| created_date | source · open nasa gov | connector:open_nasa_gov@1.0.0 | |
| description | source · open nasa gov | connector:open_nasa_gov@1.0.0 | /notes |
| license_text | source · open nasa gov | connector:open_nasa_gov@1.0.0 | |
| publication_date | source · open nasa gov | connector:open_nasa_gov@1.0.0 | |
| title | source · open nasa gov | connector:open_nasa_gov@1.0.0 | /title |
| updated_date | source · open nasa gov | connector:open_nasa_gov@1.0.0 |