Data · dataset · 2026
<p>V1WT_06 binds to the RBD site V epitope using the heavy chain alone.</p>
Listed in UCL Research Data Repository
<p><b>A)</b> A closeup view of the superimposed structure of V1WT_06 bound to WIV-1 RBD on a trimeric spike (from PDB: 8WLZ).
Description
A clash with NTD of chain B is observed when V1WT_06 Fab-RBD complex is aligned onto RBD in the up conformation (chain A) in trimeric WIV-1 spike protein. Notably, the binding site is inaccessible in the RBD-down conformation. <b>B)</b> V1WT_06 heavy chain only interaction with WIV-1 RBD (grey).
Heavy and light chains are shown with the dark and light blue ribbons, respectively. <b>C)</b> V1WT_06 epitope footprint overlayed with epitope footprints of other site V neutralising antibodies including S2H97, CC25.4, 5817, R1-32, and E465 patch [<a href="plosbiology.org/article/info:doi/10.1371/journal.pbio.3003882#pbio.3003882.ref017" target="_blank">17</a>,<a href="plosbiology.org/article/info:doi/10.1371/journal.pbio.3003882#pbio.3003882.ref027" target="_blank">27</a>–<a href="plosbiology.org/article/info:doi/10.1371/journal.pbio.3003882#pbio.3003882.ref029" target="_blank">29</a>,<a href="plosbiology.org/article/info:doi/10.1371/journal.pbio.3003882#pbio.3003882.ref035" target="_blank">35</a>].
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SARS-CoV-2 RBD (from PDB: 6m0j) is coloured based on the amino acid conservation across 87 bat sarbecoviruses [<a href="plosbiology.org/article/info:doi/10.1371/journal.pbio.3003882#pbio.3003882.ref006" target="_blank">6</a>,<a href="plosbiology.org/article/info:doi/10.1371/journal.pbio.3003882#pbio.3003882.ref023" target="_blank">23</a>,<a href="plosbiology.org/article/info:doi/10.1371/journal.pbio.3003882#pbio.3003882.ref081" target="_blank">81</a>,<a href="plosbiology.org/article/info:doi/10.1371/journal.pbio.3003882#pbio.3003882.ref082" target="_blank">82</a>]. <b>D)</b> Sequence alignment of a panel of bat sarbecovirus RBDs.
Contact residues of V1WT_06 mAb on the WIV-1-RBD are indicated with black dots. The colouring scheme describes the percent identity (PID) between the sequences as implemented in Jalview 2.11.4.0. <b>E)</b> Comparison in neutralisation potency of V1WT_06 Fab and IgG against SARS-CoV-2 (D614G), SARS-CoV-1, and WIV-1. Mean values are plotted with error bars showing ± standard deviation (s.d.).
The data underlying this Figure can be found in <a href="plosbiology.org/article/info:doi/10.1371/journal.pbio.3003882#pbio.3003882.s010" target="_blank">S1 Data</a>.</p>
Links
Where it is published
- DOI doi.org/10.1371/journal.pbio.3003882.g002 ↗
DOI / persistent id · from rdr ucl ac uk
Catalogue records · 1
- OAI-PMH record api.figshare.com/v2/oai?verb=GetRecord&metadataPrefix=oai_dc&identifier=oai%3Af… ↗
metadata API · from rdr ucl ac uk
Topics
- From keywords
- Earth & Environmental Science · Ecology · Evolutionary biology · Immunology · Infectious diseases · Life Sciences · Medicine & Health · Microbiology · Social Science · Virology
Provenance · 1 source records, 15 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| UCL Research Data Repository | oai:figshare.com:article/34048936 | 12 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · rdr ucl ac uk | connector:rdr_ucl_ac_uk@1.0.0 | |
| concepts[field].anzsrc:field:310706 | mapping · rdr ucl ac uk | vocabulary-mapper@1.0.0 | keywords['Virology'] |
| concepts[field].anzsrc:field:320211 | mapping · rdr ucl ac uk | vocabulary-mapper@1.0.0 | keywords['Infectious Diseases'] |
| concepts[field].anzsrc:group:3103 | mapping · rdr ucl ac uk | vocabulary-mapper@1.0.0 | keywords['Ecology'] |
| concepts[field].anzsrc:group:3104 | mapping · rdr ucl ac uk | vocabulary-mapper@1.0.0 | keywords['Evolutionary Biology'] |
| concepts[field].anzsrc:group:3107 | mapping · rdr ucl ac uk | vocabulary-mapper@1.0.0 | keywords['Microbiology'] |
| concepts[field].anzsrc:group:3204 | mapping · rdr ucl ac uk | vocabulary-mapper@1.0.0 | keywords['Immunology'] |
| concepts[field].local:field:earth-environmental | mapping · rdr ucl ac uk | connector:rdr_ucl_ac_uk@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · rdr ucl ac uk | connector:rdr_ucl_ac_uk@1.0.0 | |
| concepts[field].local:field:medicine-health | mapping · rdr ucl ac uk | connector:rdr_ucl_ac_uk@1.0.0 | |
| concepts[field].local:field:social-science | mapping · rdr ucl ac uk | connector:rdr_ucl_ac_uk@1.0.0 | |
| description | source · rdr ucl ac uk | connector:rdr_ucl_ac_uk@1.0.0 | /metadata/dc/description |
| license | source · rdr ucl ac uk | connector:rdr_ucl_ac_uk@1.0.0 | /metadata/dc/rights |
| publication_date | source · rdr ucl ac uk | connector:rdr_ucl_ac_uk@1.0.0 | |
| title | source · rdr ucl ac uk | connector:rdr_ucl_ac_uk@1.0.0 | /metadata/dc/title |