Data · dataset · 2026
Raw experimental dataset for Serial passaging of IBRV in MDBK cells yields a safe and live-attenuated vaccine candidate in rabbits
Listed in ScienceDB
This dataset contains all raw experimental data supporting the article "Study on Safety and Immune Effect of Attenuated IBRV-1.2/SC-37 Strain in Rabbits".
Description
The parental IBRV-1.2/SC-37 isolated from beef cattle in Sichuan was serially passaged for 100 generations on MDBK cells to obtain attenuated P100 strain. New Zealand white rabbits were used to evaluate in vivo safety, immune response and challenge protection efficacy, and analyze genome mutation features during viral attenuation.
The dataset covers 5 parts of raw data: 1. TCID₅₀ detection, plaque purification and whole-genome high-throughput sequencing results of IBRV at P10/P40/P60/P80/P100, amino acid mutation data of gB, gD, gH, TK, gE, gG and gI genes; 2. Daily body temperature, body weight, nasal/anal swab viral load qPCR raw data from 25 safety-test rabbits and 12 immunization-challenge rabbits; 3.
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Original qPCR data of viral loads in turbinate, trachea, lung, testis and penis tissues; 4. Original IgG-ELISA and serum neutralizing antibody titer data; 5. Original images including cellular CPE, viral electron micrograph, plaque staining and HE pathological sections.
Data formats include Excel spreadsheet, sequencing text, JPG images and raw qPCR files, all statistical analyses were performed via GraphPad Prism 9. All raw data support the research conclusion of the corresponding paper, which can be reused for repeated vaccine trials, molecular attenuation mechanism research of IBRV and related rabbit model studies on infectious bovine rhinotracheitis.
Links
Where it is published
- DOI doi.org/10.57760/sciencedb.39018 ↗
DOI / persistent id · from scidb cn
Catalogue records · 1
- OAI-PMH record scidb.cn/oai?verb=GetRecord&metadataPrefix=oai_dc&identifier=10.57760%2… ↗
metadata API · from scidb cn
Topics
- From keywords
- Earth & Environmental Science · Engineering · Humanities · Life Sciences · Social Science
- Inferred from text
- Image 65% · Sequencing 75% · Text 75%
Provenance · 1 source records, 13 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| ScienceDB | 10.57760/sciencedb.39018 | 11 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · scidb cn | connector:scidb_cn@1.0.0 | |
| concepts[field].local:field:earth-environmental | mapping · scidb cn | connector:scidb_cn@1.0.0 | |
| concepts[field].local:field:engineering | mapping · scidb cn | connector:scidb_cn@1.0.0 | |
| concepts[field].local:field:humanities | mapping · scidb cn | connector:scidb_cn@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · scidb cn | connector:scidb_cn@1.0.0 | |
| concepts[field].local:field:social-science | mapping · scidb cn | connector:scidb_cn@1.0.0 | |
| concepts[modality].local:modality:image | enrichment · scidb cn | keyword-concept-rules@1.0.0 | title+description (65%) |
| concepts[modality].local:modality:sequencing | enrichment · scidb cn | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[modality].local:modality:text | enrichment · scidb cn | keyword-concept-rules@1.0.0 | title+description (75%) |
| description | source · scidb cn | connector:scidb_cn@1.0.0 | /metadata/dc/description |
| license | source · scidb cn | connector:scidb_cn@1.0.0 | /metadata/dc/rights |
| publication_date | source · scidb cn | connector:scidb_cn@1.0.0 | |
| title | source · scidb cn | connector:scidb_cn@1.0.0 | /metadata/dc/title |