Supporting data for "Antioxidant Nanoparticle-Armored Probiotics within a Programmable Supramolecular Hydrogel for Stage-Specific Periodontitis Therapy"

The platform combines PP nanoparticle-functionalized Lf with a CMC–CPP–CB hydrogel to achieve sustained local delivery, antibacterial activity, and NIR-responsive photothermal treatment. Its therapeutic potential is assessed against periodontal pathogens such as Fusobacterium nucleatum and Porphyromonas gingivalis, together with its ability to regulate LPS-induced inflammatory responses.

The study integrates material characterization, hydrogel rheology, photothermal evaluation, antibacterial testing, and cellular analyses to investigate the potential of this system as a combined antimicrobial and immunomodulatory strategy for periodontal therapy.</p>