Data · dataset · 2026
Investigating the role of the secretory leukocyte protease inhibitor (SLPI) in lung adenocarcinoma
Listed in ZivaHub and Deakin Research Online and DMU Figshare — shown once because both records carry DOI 10.17034/32634507.v1
Secretory leukocyte protease inhibitor (SLPI) is an 11.7kDa serine protease inhibitor, which possesses anti-protease, anti-inflammatory, and anti-microbial properties.
Description
However, SLPI is reported to acquire pathogenic features in diseases such as cancer. Indeed, SLPI has been identified to be significantly increased in lung cancer patient plasma, with further increased SLPI levels observed with metastatic disease.
In this thesis it was hypothesised that SLPI is aiding tumourigenesis by influencing the Hallmarks of Cancer. Significantly reduced xenograft tumour burden was identified in SLPr/_ mice with significantly decreased functional blood vessel number compared to tumours from WT mice. Further investigation revealed the addition of recombinant human SLPI (rSLPI) to human umbilical vein endothelial cells (HUVEC) significantly increased enclosed structure number, with substantially reduced p- VEGF R2 levels in tumours from SLPI7' mice.
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Increased SLPI levels have been identified in chronic obstructive pulmonary disease (COPD) patient BAL fluid where it is thought to be beneficial due to its functional properties. Therefore, the PENaC-Tg model of chronic inflammatory lung disease was utilised to evaluate the effect of host SLPI loss in this COPD- like model. Results demonstrated significantly increased inflammatory cell counts in (3ENaC- Tg SLPI7' mouse BAL fluid compared to PENaC-Tg mice.
No substantial difference was observed in airspace enlargement and destruction between PENaC-Tg mice and pENaC-Tg SLPI7' mice. Increased expression of syndecan-4 in PENaC-Tg SLPImice was identified compared to WT, SLPI', and PENaC-Tg mice. Therefore, it was postulated that there may be potentially elevated NE activity in the PENaC-Tg SLPI7 mice, which increases shedding of syndecan-4 and therefore heightened inflammation.
In conclusion, SLPI promotes 3LL lung adenocarcinoma tumourigenesis by increasing neo-vascularisation but reduces lung inflammation in a COPD-like murine model.
Links
Where it is published
- DOI doi.org/10.17034/32634507.v1 ↗
DOI / persistent id · from zivahub uct ac za
Catalogue records · 1
- OAI-PMH record api.figshare.com/v2/oai?verb=GetRecord&metadataPrefix=oai_dc&identifier=oai%3Af… ↗
metadata API · from zivahub uct ac za
Topics
Provenance · 3 source records, 9 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| ZivaHub | oai:figshare.com:article/32634507 | 10 d ago | JSON v1 |
| Deakin Research Online | oai:figshare.com:article/32634507 | 10 d ago | JSON v1 |
| DMU Figshare | oai:figshare.com:article/32634507 | 10 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| concepts[disease].local:disease:cancer | enrichment · zivahub uct ac za | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[disease].local:disease:disease | enrichment · zivahub uct ac za | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[field].local:field:earth-environmental | mapping · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | |
| concepts[field].local:field:earth-environmental | mapping · dro deakin edu au | connector:dro_deakin_edu_au@1.0.0 | |
| concepts[field].local:field:earth-environmental | mapping · figshare dmu ac uk | connector:figshare_dmu_ac_uk@1.0.0 | |
| description | source · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | /metadata/dc/description |
| license_text | source · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | |
| publication_date | source · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | |
| title | source · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | /metadata/dc/title |