Combinatorial RiPP biosynthesis for the generation of gene-encoded new-to-nature peptide antimicrobials

In this thesis we constructed several new biosynthetic pathways, combining RiPP post-translational modification enzymes to act on a single peptide to synthesize new-to-nature antimicrobial peptides that mimic several potent non-ribosomal peptide antibiotics.

These files contains data belonging to the three experimental chapters of the thesis and include mass spectrometry figures, LC-MS analysis figures, precursor peptide sequences, primer sequences and the supplementary information references.