"Multi-organ Proteomic Landscape of COVID-19 Autopsies" A study of Nie et al

Here, we report an in-depth multi-organ proteomic landscape of COVID-19 autopsy samples. By integrative analysis of seven-organ proteomes, namely lung, spleen, liver, heart, kidney, thyroid and testis, we quantified 11,394 proteins, in which 5336 were perturbed in theCOVID-19 patients compared to controls.

Our data showed that CTSL, rather than ACE2, was significantly upregulated in the lung from the COVID-19 patients. Dysregulation of protein translation, glucose metabolism, fatty acid metabolism was detected in multiple organs. Our data suggested upon SARS-CoV-2 infection, hyperinflammation might be triggered, leading to hypoxia, angiogenesis, blood coagulation and fibrosis in the multiple organs.