Structure · dataset · 2026
Pluronic F127 Micelles Co-encapsulating a Brachydin-Enriched Fraction and Curcumin: A Self-assembled Platform for Light-assisted Antileishmanial Activity
Listed in ZivaHub and Deakin Research Online and DMU Figshare — shown once because both records carry DOI 10.1021/acsomega.6c05278.s001
This study developed an associative Pluronic F127-based formulation co-loaded with a brachydin-enriched fraction and curcumin (FBC) for preliminary light-assisted antileishmanial evaluation.
Description
The formulation showed high apparent active-material recovery after centrifugation and filtration, as estimated by HPLC-PDA. DLS analysis indicated a polydisperse colloidal profile, with an apparent mean hydrodynamic diameter of approximately 406.5 nm and a number-weighted smaller population centered at approximately 12.1 nm.
FTIR data were consistent with formulation-related changes in the vibrational environment of the hydrophobic active materials, while AFM and SEM provided complementary morphological information on deposited or dried samples. Together, these data support an interpretative F127-based self-assembly model, without establishing a fully uniform colloidal population or a definitively resolved internal micellar architecture. In vitro cytotoxicity assays using GM07492A human lung fibroblasts indicated low basal cytotoxicity under dark conditions, whereas light exposure produced concentration-dependent viability reductions at higher formulation concentrations.
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Antileishmanial assays against Leishmania amazonensis promastigotes revealed a marked light-associated response, mainly in formulations containing the brachydin-enriched fraction. FB showed the highest potency under light exposure, with a formulation-based IC<sub>50</sub> of 18.63 μg mL<sup>–1</sup>, whereas FBC showed an IC<sub>50</sub> decrease from 72.74 to 34.33 μg mL<sup>–1</sup>. Thus, although FBC was not more potent than FB, it combined light-associated antileishmanial activity, high apparent active-material recovery, and favorable macroscopic formulation behavior.
Because FB and FBC contain a brachydin-enriched fraction rather than purified individual brachydins, the biological responses should be interpreted as preliminary formulation-level effects. Further studies involving direct reactive oxygen species measurements, intracellular amastigote assays, formal selectivity analysis, fraction standardization, and long-term colloidal stability evaluation are still required before therapeutic efficacy can be inferred.
Links
Where it is published
- DOI doi.org/10.1021/acsomega.6c05278.s001 ↗
DOI / persistent id · from zivahub uct ac za
Catalogue records · 1
- OAI-PMH record api.figshare.com/v2/oai?verb=GetRecord&metadataPrefix=oai_dc&identifier=oai%3Af… ↗
metadata API · from zivahub uct ac za
Topics
- From keywords
- Biochemistry and cell biology · Biochemistry and cell biology · Biochemistry and cell biology · Cancer · Cancer · Cancer · Chemistry · Chemistry · Chemistry · Earth & Environmental Science · Earth & Environmental Science · Earth & Environmental Science · Ecology · Ecology · Ecology · Inorganic chemistry · Inorganic chemistry · Inorganic chemistry · Life Sciences · Life Sciences · Life Sciences · Medicine & Health · Medicine & Health · Medicine & Health
Provenance · 3 source records, 29 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| ZivaHub | oai:figshare.com:article/34046528 | 10 d ago | JSON v1 |
| Deakin Research Online | oai:figshare.com:article/34046528 | 10 d ago | JSON v1 |
| DMU Figshare | oai:figshare.com:article/34046528 | 10 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
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| concepts[disease].local:disease:cancer | mapping · figshare dmu ac uk | vocabulary-mapper@1.0.0 | keywords['Cancer'] |
| concepts[disease].local:disease:cancer | mapping · dro deakin edu au | vocabulary-mapper@1.0.0 | keywords['Cancer'] |
| concepts[field].anzsrc:group:3101 | mapping · zivahub uct ac za | vocabulary-mapper@1.0.0 | keywords['Cell Biology'] |
| concepts[field].anzsrc:group:3101 | mapping · figshare dmu ac uk | vocabulary-mapper@1.0.0 | keywords['Cell Biology'] |
| concepts[field].anzsrc:group:3101 | mapping · dro deakin edu au | vocabulary-mapper@1.0.0 | keywords['Cell Biology'] |
| concepts[field].anzsrc:group:3103 | mapping · zivahub uct ac za | vocabulary-mapper@1.0.0 | keywords['Ecology'] |
| concepts[field].anzsrc:group:3103 | mapping · dro deakin edu au | vocabulary-mapper@1.0.0 | keywords['Ecology'] |
| concepts[field].anzsrc:group:3103 | mapping · figshare dmu ac uk | vocabulary-mapper@1.0.0 | keywords['Ecology'] |
| concepts[field].anzsrc:group:3402 | mapping · figshare dmu ac uk | vocabulary-mapper@1.0.0 | keywords['Inorganic Chemistry'] |
| concepts[field].anzsrc:group:3402 | mapping · dro deakin edu au | vocabulary-mapper@1.0.0 | keywords['Inorganic Chemistry'] |
| concepts[field].anzsrc:group:3402 | mapping · zivahub uct ac za | vocabulary-mapper@1.0.0 | keywords['Inorganic Chemistry'] |
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| concepts[field].local:field:chemistry | mapping · dro deakin edu au | connector:dro_deakin_edu_au@1.0.0 | |
| concepts[field].local:field:chemistry | mapping · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | |
| concepts[field].local:field:earth-environmental | mapping · dro deakin edu au | connector:dro_deakin_edu_au@1.0.0 | |
| concepts[field].local:field:earth-environmental | mapping · figshare dmu ac uk | connector:figshare_dmu_ac_uk@1.0.0 | |
| concepts[field].local:field:earth-environmental | mapping · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · dro deakin edu au | connector:dro_deakin_edu_au@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · figshare dmu ac uk | connector:figshare_dmu_ac_uk@1.0.0 | |
| concepts[field].local:field:medicine-health | mapping · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | |
| concepts[field].local:field:medicine-health | mapping · figshare dmu ac uk | connector:figshare_dmu_ac_uk@1.0.0 | |
| concepts[field].local:field:medicine-health | mapping · dro deakin edu au | connector:dro_deakin_edu_au@1.0.0 | |
| description | source · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | /metadata/dc/description |
| license | source · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | /metadata/dc/rights |
| publication_date | source · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | |
| title | source · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | /metadata/dc/title |