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Excel · study · 2026

Transcriptomic analysis of DHODH inhibition in PIK3CA-mutant colorectal cancer

Listed in NCBI GEO

This study investigates the transcriptional consequences of genetic and pharmacological DHODH inhibition in PIK3CA-mutant colorectal cancer.

Description

RNA sequencing was performed in RKO cells following either DHODH knockdown (shDHODH versus shNT) or treatment with the DHODH inhibitor HL6 (HL6 versus DMSO) to characterize the transcriptional programs regulated by DHODH and compare the effects of genetic and pharmacological inhibition.

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Topics

Stated by source
Expression profiling by high throughput sequencing
From keywords
Life Sciences
Inferred from text
Cancer 75% · RNA sequencing 75% · Sequencing 75%
Provenance · 1 source records, 9 field assertions
SourceKeyLast seenRaw
NCBI GEOGSE33569313 d agoJSON v1
FieldAssertionExtractorEvidence
access_levelsource · NCBI GEOconnector:ncbi_geo@1.0.0
concepts[disease].local:disease:cancerenrichment · NCBI GEOkeyword-concept-rules@1.0.0title+description (75%)
concepts[field].local:field:life-sciencesmapping · NCBI GEOconnector:ncbi_geo@1.0.0
concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencingsource · NCBI GEOconnector:ncbi_geo@1.0.0/gdstype
concepts[modality].local:modality:rna-seqenrichment · NCBI GEOkeyword-concept-rules@1.0.0title+description (75%)
concepts[modality].local:modality:sequencingenrichment · NCBI GEOkeyword-concept-rules@1.0.0title+description (75%)
descriptionsource · NCBI GEOconnector:ncbi_geo@1.0.0/summary
publication_datesource · NCBI GEOconnector:ncbi_geo@1.0.0
titlesource · NCBI GEOconnector:ncbi_geo@1.0.0/title