<p>Impact of biasing receptor distribution on cAMP production using dose-response analysis.</p>

<p>In the different panels, the ligand (M) dose response relationship of model 2 (<a href="ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.1014790#pcbi.1014790.g003" target="_blank">Fig 3</a>) is plotted for different values of <i>p</i>₂₃. The values of <i>p</i>₂₃ represent the increasing of receptors in the third compartment. Common parameters are <i>p</i>₂₃ = 0 (dotted line), <i>p</i>₂₃ = 0.3 (dashdot line), <i>p</i>₂₃ = 0.7 (dashed line) and <i>p</i>₂₃ = 1 (solid line),; , <i>R</i>₀ = 1, <i>k</i>^– = 1, , , , , whereas the recycling ( and ) and production ( and ) parameters are specific to each panel: <b>(A)</b> , , , ; <b>(B)</b> , , , ; <b>(C)</b> , , , ; <b>(D)</b> , , , .

Circles represent the value of <i>EC</i>₅₀. Parameter values were arbitrarily chosen, for illustration purposes.</p>