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Omics · study · 2026

Dynamic Supramolecular Hydrogel Reprogram Probiotic Metabolism and Enhance Therapeutic Efficacy in Periodontitis

Listed in NCBI GEO

Hydrogel network dynamics can influence the biological function of encapsulated probiotics.

Description

We performed RNA sequencing to compare the transcriptional profiles of Lacticaseibacillus paracasei encapsulated in dynamic supramolecular (Lp@PP) and static covalently crosslinked (Lp@BM) hydrogels. Our analysis revealed distinct growth-associated and stress-adaptive transcriptional programs in Lp@PP and Lp@BM, respectively.

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Expression profiling by high throughput sequencing
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Life Sciences
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RNA sequencing 75% · Sequencing 75%
Provenance · 1 source records, 8 field assertions
SourceKeyLast seenRaw
NCBI GEOGSE34699012 d agoJSON v1
FieldAssertionExtractorEvidence
access_levelsource · NCBI GEOconnector:ncbi_geo@1.0.0
concepts[field].local:field:life-sciencesmapping · NCBI GEOconnector:ncbi_geo@1.0.0
concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencingsource · NCBI GEOconnector:ncbi_geo@1.0.0/gdstype
concepts[modality].local:modality:rna-seqenrichment · NCBI GEOkeyword-concept-rules@1.0.0title+description (75%)
concepts[modality].local:modality:sequencingenrichment · NCBI GEOkeyword-concept-rules@1.0.0title+description (75%)
descriptionsource · NCBI GEOconnector:ncbi_geo@1.0.0/summary
publication_datesource · NCBI GEOconnector:ncbi_geo@1.0.0
titlesource · NCBI GEOconnector:ncbi_geo@1.0.0/title