A simple and convenient protocol for the synthesis of seven- and eight-membered phosphorus heterocycles

A simple procedure for the synthesis of eight-membered 6-(2-chloroethyl)/bis(2-chloroethyl)-amino-12-oxo-dibenzo[d,g][1,3,2]dioxaphosphocin 6-oxides ( 3a–b ) and seven-membered 6-(2-chloroethyl)/bis-(2-chloroethyl)aminodibenzo[d,f][1,3,2]dioxaphosphepin 6-oxides ( 5a–b ) from cyclocondensation of equimolar ratios of 2,2′-dihydroxybenzophenone ( 1 ) and 2,2′-dihydroxybiphenol ( 4 ), respectively with 2-chloroethylphosphonicdichloride ( 2a ) and bis(2-chloroethyl)phosphoramidic dichloride ( 2b ) in dry toluene in the presence of triethylamine at 45–50 °C is described.

All synthesized compounds possessed significant growth inhibition for their antibacteria against ‘Bacillus subtilis’ and ‘Klebsiella pneumonia’ and antifungi activity on “Curvularia lunata” and “Aspergillus niger.”