Data · dataset · 2026
QUB-1439: A bioactive peptide from the frog skin secretion of Hylarana guentheri
Listed in ZivaHub and Deakin Research Online and DMU Figshare — shown once because both records carry DOI 10.17034/32863025.v1
Antimicrobial peptides (AMPs) are a sufficient and diverse group of molecules that are derive from various invertebrate, plant and animal species.
Description
AMPs possess a variety of biological activity, such as anticancer, antivirus and so on. Nowadays, a growing number of AMPs are considered as promising candidate of new drug. <br><br>This thesis focused on the antimicrobial peptide (QUB-1439) which was isolated from the skin secretion of Hylarna guentheri.
It is the first time to identify the biosynthetic precursor encoding cDNA of QUB-1439 from the skin secretion-derived cDNA library though the mature peptide sequence, FLPLLFGAISHLL-NH2, has been identified before. Subsequently, QUB-1439 was synthesised by Tribute peptide synthesiser. Then, MALDI-TOF was used to check the molecular weight of the synthetic peptide.
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The crude peptide was purified by RP-HPLC. Finally, a series assays were performed to test the bioactivities of purified QUB-1439, including antimicrobial assay, anticancer assay and haemolysis assay. The results showed that QUB-1439 has ability to inhibit the growth of Gram-positive bacteria, the MIC of QUB-1439 against S. aureus is 16 μM. QUB-1439 does not exhibit toxicity and it has a weak effect on inhibition of cancer cell growth.
Because QUB-1439 has these promising properties, it could be developped into a novel drug.<br>
Links
Where it is published
- DOI doi.org/10.17034/32863025.v1 ↗
DOI / persistent id · from zivahub uct ac za
Catalogue records · 1
- OAI-PMH record api.figshare.com/v2/oai?verb=GetRecord&metadataPrefix=oai_dc&identifier=oai%3Af… ↗
metadata API · from zivahub uct ac za
Topics
- From keywords
- Earth & Environmental Science · Earth & Environmental Science · Earth & Environmental Science
- Inferred from text
- Cancer 75%
Provenance · 3 source records, 8 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| ZivaHub | oai:figshare.com:article/32863025 | 10 d ago | JSON v1 |
| Deakin Research Online | oai:figshare.com:article/32863025 | 10 d ago | JSON v1 |
| DMU Figshare | oai:figshare.com:article/32863025 | 10 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| concepts[disease].local:disease:cancer | enrichment · zivahub uct ac za | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[field].local:field:earth-environmental | mapping · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | |
| concepts[field].local:field:earth-environmental | mapping · dro deakin edu au | connector:dro_deakin_edu_au@1.0.0 | |
| concepts[field].local:field:earth-environmental | mapping · figshare dmu ac uk | connector:figshare_dmu_ac_uk@1.0.0 | |
| description | source · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | /metadata/dc/description |
| license_text | source · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | |
| publication_date | source · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | |
| title | source · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | /metadata/dc/title |