Clinical Dataset of Lip Mucosa Barrier Improvement and Oral Microbiota Exploration of a Lip Balm Product in Populations with Different Breathing Modes

It contains clinical test and sequencing data of 66 subjects aged 18–65 years, divided into mouth-breathing experimental group and nose-breathing control group with 33 cases each. All subjects used Bishengzhiyan Lip Soothing Repair Ointment 4 times daily for 4 consecutive weeks.

Data were collected at three time points: baseline Day 0, 15 minutes after product application, and 4-week follow-up. The dataset covers 4 categories of data: ① non-invasive instrumental measurements including lip TEWL, stratum corneum hydration, erythema value and lip mucosa OCT images; ② clinician semi-quantitative scores for lip dryness, scaling, stinging and edema; ③ oral mucosal microbial sequencing data including Shannon/Simpson diversity indices and relative abundance of dominant flora; ④ full safety records of adverse events, demographic baseline information and subject compliance logs.