Table · dataset · 2025
Comprehensive multi-omics analysis reveals mitochondrial stress as a central biological hub for spaceflight impact
Listed in NASA Data Portal
Given the limited knowledge of the biological impact of spaceflight, a multi-omics, systems biology approach was used to investigate NASA’s GeneLab data and astronaut biomedical profiles.
Description
These data consist of hundreds of samples flown in space, human metrics from 59 astronauts, and confirmatory data from NASA’s Twin Study, analyzed together for consistent transcriptomic, proteomic, metabolomic, and epigenetic response to spaceflight.
Pathway analysis showed significant enrichment of mitochondrial activity and innate immunity. Muscle and liver tissues showed that chronic inflammation, may be a response to mitochondrial dysfunction. Additional pathways altered in spaceflight included cell cycle, circadian rhythm, and olfactory activity pathways, all of which are known to have interactions with mitochondrial activity.
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Evidence of altered mitochondrial function was also found in the urine and blood metabolic data compiled from the astronaut cohort and NASA Twin Study data, all of which indicate mitochondrial stress as a consistent phenotype of spaceflight.
Links
Get the data
- Resource lsda.jsc.nasa.gov/Experiment/exper/13964 ↗
download · from data nasa gov
- Resource osdr.nasa.gov/bio/repo/data/studies/OSD-343 ↗
download · from data nasa gov
- Resource lsda.jsc.nasa.gov/Mission/miss/1400 ↗
download · from data nasa gov
- Resource purl.bioontology.org/ontology/NCBITAXON/10090 ↗
download · from data nasa gov
Where it is published
- NASA Data Portal dataset page data.nasa.gov/dataset/comprehensive-multi-omics-analysis-reveals-mitochondri… ↗
landing page · from data nasa gov
- DOI doi.org/10.26030/h968-2m75 ↗
DOI / persistent id · from data nasa gov
Catalogue records · 1
- CKAN API data.nasa.gov/api/3/action/package_show?id=378c1ba8-7dd3-4449-9e23-137e24001… ↗
metadata API · from data nasa gov
Topics
- From keywords
- Astronomy & Astrophysics · Earth & Environmental Science · Life Sciences · Ocean & Atmospheric Science · Physics
- Inferred from text
- Bioinformatics and computational biology 73%
Provenance · 1 source records, 12 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NASA Data Portal | 378c1ba8-7dd3-4449-9e23-137e24001a43 | 9 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| concepts[field].anzsrc:group:3102 | enrichment · data nasa gov | taxonomy-embedding@1.0.0 | title+keywords+description (73%) |
| concepts[field].local:field:astronomy | mapping · data nasa gov | connector:data_nasa_gov@1.0.0 | |
| concepts[field].local:field:earth-environmental | mapping · data nasa gov | connector:data_nasa_gov@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · data nasa gov | connector:data_nasa_gov@1.0.0 | |
| concepts[field].local:field:ocean-atmospheric | mapping · data nasa gov | connector:data_nasa_gov@1.0.0 | |
| concepts[field].local:field:physics | mapping · data nasa gov | connector:data_nasa_gov@1.0.0 | |
| created_date | source · data nasa gov | connector:data_nasa_gov@1.0.0 | |
| description | source · data nasa gov | connector:data_nasa_gov@1.0.0 | /notes |
| license_text | source · data nasa gov | connector:data_nasa_gov@1.0.0 | |
| publication_date | source · data nasa gov | connector:data_nasa_gov@1.0.0 | |
| title | source · data nasa gov | connector:data_nasa_gov@1.0.0 | /title |
| updated_date | source · data nasa gov | connector:data_nasa_gov@1.0.0 |