Data · dataset · 2022
Selective α-Methylation of Aryl Ketones Using Quaternary Ammonium Salts as Solid Methylating Agents
Listed in TU Wien Research Data
Analytical Data and Compound Numbering (in paper numbering vs. ELN entries) for the Publication entitled: "Selective α-Methylation of Aryl Ketones Using Quaternary Ammonium Salts as Solid Methylating Agents" The paper was published on 2022-03-07 in the Journal of Organic Chemistry.
Description
J. Org. Chem. 2022, 87, 6, 4305–4315 DOI: 10.1021/acs.joc.1c03158 Authors: Johanna Templ and Michael Schnürch Funded by the Austrian Science Fund (FWF, project number P33064-N) Context and methodology In this Publication, we describe the use of phenyl trimethylammonium iodide (PhMe3NI) as an alternative methylating agent for introducing a CH3 group in α-position to a carbonyl group.
Compared to conventional methylating agents, quaternary ammonium salts have the advantages of being nonvolatile, noncancerogenic, and easy-to-handle solids. This regioselective method is characterized by ease of operational setup, use of anisole as green solvent, and yields up to 85%. The publication and its Supporting Information can be found as open-access files on the publisher's website (see DOI above).
Read the rest (2 more)
All detailed files containing the analytical raw data, for all compounds given in the Supporting Information of the manuscript are uploaded. An additional Word file named J. Org. Chem. 2022, 87, 6, 4305-4315_coumpound number list.pdf is uploaded, that should clearly link the compound number given in the paper to the respective entry in the ELN (jotempl) and the respective analytical data files.
Technical details The files uploded contain the FIDs of NMR spectra recorded by an in-house Bruker Spectrometer. A software to display NMR-spectra is needed, such as MestreNova or Topspin . HRMS data is uploaded too and has to be processed via MassHunter software.
Links
Where it is published
- TU Wien Research Data record researchdata.tuwien.ac.at/records/zf7m0-efz76 ↗
landing page · from researchdata tuwien ac at
- DOI doi.org/10.48436/zf7m0-efz76 ↗
DOI / persistent id · from researchdata tuwien ac at
Catalogue records · 1
- InvenioRDM API researchdata.tuwien.ac.at/api/records/zf7m0-efz76 ↗
metadata API · from researchdata tuwien ac at
Topics
- Stated by source
- ethylation · methodology · methylation · quaternary ammonium salts
- Inferred from text
- Organic chemistry 73%
Provenance · 1 source records, 12 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| TU Wien Research Data | zf7m0-efz76 | 8 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · researchdata tuwien ac at | connector:researchdata_tuwien_ac_at@1.0.0 | |
| concepts[field].anzsrc:group:3405 | enrichment · researchdata tuwien ac at | taxonomy-embedding@1.1.0 | title+keywords+description (73%) |
| concepts[topic].invenio_subject:researchdata_tuwien_ac_at:ethylation | source · researchdata tuwien ac at | connector:researchdata_tuwien_ac_at@1.0.0 | |
| concepts[topic].invenio_subject:researchdata_tuwien_ac_at:methodology | source · researchdata tuwien ac at | connector:researchdata_tuwien_ac_at@1.0.0 | |
| concepts[topic].invenio_subject:researchdata_tuwien_ac_at:methylation | source · researchdata tuwien ac at | connector:researchdata_tuwien_ac_at@1.0.0 | |
| concepts[topic].invenio_subject:researchdata_tuwien_ac_at:quaternary-ammonium-salts | source · researchdata tuwien ac at | connector:researchdata_tuwien_ac_at@1.0.0 | |
| description | source · researchdata tuwien ac at | connector:researchdata_tuwien_ac_at@1.0.0 | /metadata/description |
| license | source · researchdata tuwien ac at | connector:researchdata_tuwien_ac_at@1.0.0 | |
| publication_date | source · researchdata tuwien ac at | connector:researchdata_tuwien_ac_at@1.0.0 | |
| title | source · researchdata tuwien ac at | connector:researchdata_tuwien_ac_at@1.0.0 | /metadata/title |
| updated_date | source · researchdata tuwien ac at | connector:researchdata_tuwien_ac_at@1.0.0 | |
| version_label | source · researchdata tuwien ac at | connector:researchdata_tuwien_ac_at@1.0.0 |