Table 1_Psychiatric morbidity is associated with cognitive impairment, whereas diagnostic category may shape its profile: a transdiagnostic study of inflammation, salivary biomarkers, and health-related quality of life.docx

Exploratory diagnosis-specific analyses suggested heterogeneity in cognitive, inflammatory, and psychosocial profiles. NLR was associated with psychiatric morbidity but was not independently associated with cognitive impairment. SYP showed an exploratory association with cognitive impairment (OR = 0.993 per ng/mL increase; corresponding OR = 0.681 across the observed interquartile range), although this finding was attenuated in sensitivity analyses and should be interpreted cautiously.

Subjective distress was not independently associated with diagnosis or biomarkers but was strongly associated with health-related quality of life (HRQoL) (SF-12 physical and mental components; Nagelkerke R² = 0.734), indicating a distinct psychosocial dimension; however, this finding should be interpreted cautiously because of conceptual overlap between self-reported constructs.</p>Limitations<p>Cross-sectional design precludes causal inference.

Sample size limits statistical power for diagnostic subgroup comparisons. The neuropsychological assessor was not blinded to participants’ diagnostic status. Universal psychopharmacological treatment precludes disentangling illness from medication effects.</p>Conclusion<p>Psychiatric morbidity was associated with the presence of cognitive impairment in this baseline cross-sectional analysis, whereas the diagnostic category may contribute to heterogeneity in the impairment profile.

Systemic inflammation was associated with psychiatric morbidity but was not independently associated with cognitive impairment. Subjective distress was strongly associated with HRQoL and appeared largely independent of the biological markers examined. These findings support an integrative multilevel framework in which cognitive impairment and HRQoL represent complementary transdiagnostic dimensions.

Routine cognitive screening across psychiatric settings may be warranted. The observed SYP and HRQoL associations should be considered hypothesis-generating and require longitudinal validation.</p>