Data · dataset · 2026
In Vitro Exposure Assessment Improves Hazard Ranking of Bisphenol A Alternatives
Listed in ZivaHub and Deakin Research Online and DMU Figshare — shown once because both records carry DOI 10.1021/acs.chemrestox.6c00300.s001
<i>In vitro</i> toxicity data can be used for comparative hazard assessment of the problematic plastic chemical bisphenol A (BPA) and its replacement chemicals.
Description
Hazard assessment is exclusively based on nominal effect concentrations of the BPA alternatives, but due to their diversity of physicochemical properties and stability, this may lead to inaccurate hazard ranking. In the present study, chemical stability as well as freely dissolved concentrations (<i>C</i><sub>free</sub>) were determined for BPA and 24 of its alternatives.
BPA and 22 alternatives were found to be stable in bioassay medium for up to 48 h. The diglycidyl ether of BPA (BADGE) was completely degraded in medium. For BPPH, a loss of up to 37% was observed.
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A mass balance model was used to derive <i>C</i><sub>free</sub> of the stable chemicals in the bioassay medium. For model validation, <i>C</i><sub>free</sub> in bioassay medium, as well as binding to proteins and membrane lipids, was measured for BPA and 15 of the alternatives. Experimentally determined <i>C</i><sub>free</sub> agreed with model predictions within a factor of 10.
Relative effect potencies (REPs) of the BPA alternatives compared to BPA were calculated based on nominal (REP<sub>nom</sub>) and freely dissolved effect concentrations (REP<sub>free</sub>) for two representative end points (activation of estrogen receptor α and inhibition of mitochondrial membrane potential). For hydrophilic and moderately hydrophobic BPA alternatives, REP<sub>nom</sub> and REP<sub>free</sub> agreed well.
REP<sub>free</sub> was up to 147× higher compared to REP<sub>nom</sub> for hydrophobic and highly protein-bound alternatives like TCBPA or BPAF. BP-MIBK had the highest estrogenic potential based on REP<sub>nom</sub>, but the highly protein-bound BPAF was identified as most potent based on REP<sub>free</sub>. TCBPA has a lower estrogenic potential than BPA based on REP<sub>nom</sub> (0.11), but based on REP<sub>free</sub> (12.8), it is more potent than BPA.
The results of the present study highlight the need to correct for different <i>in vitro</i> exposure conditions to allow accurate hazard ranking.
Links
Where it is published
- DOI doi.org/10.1021/acs.chemrestox.6c00300.s001 ↗
DOI / persistent id · from zivahub uct ac za
Catalogue records · 1
- OAI-PMH record api.figshare.com/v2/oai?verb=GetRecord&metadataPrefix=oai_dc&identifier=oai%3Af… ↗
metadata API · from zivahub uct ac za
Topics
- From keywords
- Cancer · Cancer · Cancer · Chemistry · Chemistry · Chemistry · Earth & Environmental Science · Earth & Environmental Science · Earth & Environmental Science · Ecology · Ecology · Ecology · Life Sciences · Life Sciences · Life Sciences · Medicine & Health · Medicine & Health · Medicine & Health
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- Possibly the same asIn Vitro Exposure Assessment Improves Hazard Ranking of Bisphenol A Alternatives
Provenance · 3 source records, 23 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| ZivaHub | oai:figshare.com:article/34033421 | 10 d ago | JSON v1 |
| Deakin Research Online | oai:figshare.com:article/34033421 | 10 d ago | JSON v1 |
| DMU Figshare | oai:figshare.com:article/34033421 | 10 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | |
| concepts[disease].local:disease:cancer | mapping · zivahub uct ac za | vocabulary-mapper@1.0.0 | keywords['Cancer'] |
| concepts[disease].local:disease:cancer | mapping · figshare dmu ac uk | vocabulary-mapper@1.0.0 | keywords['Cancer'] |
| concepts[disease].local:disease:cancer | mapping · dro deakin edu au | vocabulary-mapper@1.0.0 | keywords['Cancer'] |
| concepts[field].anzsrc:group:3103 | mapping · zivahub uct ac za | vocabulary-mapper@1.0.0 | keywords['Ecology'] |
| concepts[field].anzsrc:group:3103 | mapping · dro deakin edu au | vocabulary-mapper@1.0.0 | keywords['Ecology'] |
| concepts[field].anzsrc:group:3103 | mapping · figshare dmu ac uk | vocabulary-mapper@1.0.0 | keywords['Ecology'] |
| concepts[field].local:field:chemistry | mapping · dro deakin edu au | connector:dro_deakin_edu_au@1.0.0 | |
| concepts[field].local:field:chemistry | mapping · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | |
| concepts[field].local:field:chemistry | mapping · figshare dmu ac uk | connector:figshare_dmu_ac_uk@1.0.0 | |
| concepts[field].local:field:earth-environmental | mapping · dro deakin edu au | connector:dro_deakin_edu_au@1.0.0 | |
| concepts[field].local:field:earth-environmental | mapping · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | |
| concepts[field].local:field:earth-environmental | mapping · figshare dmu ac uk | connector:figshare_dmu_ac_uk@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · dro deakin edu au | connector:dro_deakin_edu_au@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · figshare dmu ac uk | connector:figshare_dmu_ac_uk@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | |
| concepts[field].local:field:medicine-health | mapping · dro deakin edu au | connector:dro_deakin_edu_au@1.0.0 | |
| concepts[field].local:field:medicine-health | mapping · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | |
| concepts[field].local:field:medicine-health | mapping · figshare dmu ac uk | connector:figshare_dmu_ac_uk@1.0.0 | |
| description | source · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | /metadata/dc/description |
| license | source · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | /metadata/dc/rights |
| publication_date | source · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | |
| title | source · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | /metadata/dc/title |