Supplementary file 1_Exploring the psychogastroenterology patterns of functional dyspepsia and irritable bowel syndrome comorbidities based on latent profile analysis.docx

The heterogeneity of clinical appearance of these comorbidities causes difficulties with individualized diagnosis and comprehensive treatment of FGIDs. In this study, we aimed to estimate and interpret the psychology–gastroenterology interaction patterns of FGIDs for heterogeneous clinical appearances against the traditional anatomic diagnosis criteria.</p>Methods<p>In a retrospective cross-sectional study, the intensities of clinical appearances covering gastrointestinal symptoms, systemic symptoms, psychological disorders, and environmental sensitivity were collected using a self-administered questionnaire.

Then, a multidimensional assessment framework was applied to estimate the quantitative model using structural equation modeling (SEM) and item response theory (IRT). The latent traits of each patient were evaluated using multidimensional computerized adaptive testing (MCAT). Lastly, the clinical patterns were estimated using either the original symptom intensity or quantified trait scores to interpret the psychology–gastroenterology interaction characteristics of FGIDs.</p>Results<p>A total of 996 patients diagnosed with functional dyspepsia (FD) or irritable bowel syndrome (IBS) were enrolled in the study; the comorbidities of these two subtypes were observed along with the heterogeneities of their clinical appearances.