Data · dataset · 2026
The discovery of a novel bioactive peptide, QUB-1036, from the defensive skin secretion of Pelophylax kl. esculentus
Listed in ZivaHub and Deakin Research Online and DMU Figshare — shown once because both records carry DOI 10.17034/32862614.v1
Gene-coded antimicrobial peptides (AMPs) are a great source of natural antimicrobial agents and good models for the design of new generation antibiotics.
Description
In the meantime, a large number of AMPs have been isolated and characterised from different amphibian species due to their special skin structure and strong adaptability to most types of environment with complex microorganisms.<br>In this thesis, a novel peptide named QUB-1036 was identified from the lyophilised skin secretion of the European edible frog, Pelophylax kl. esculentus, by both a ‘shotgun’ cloning genomic study and a peptidomic study.
After chemical synthesis, QUB-1036 was subjected to bioactivity tests. As a result, QUB-1036 was observed to have no inhibition against microbial growth and was completely devoid of haemolytic activity. It is noteworthy that the novel peptide, QUB-1036, was found to be a bradykinin receptor agonist on rat bladder and uterus.
Read the rest (1 more)
This is one of the few reports of bioactive peptides from the temporin family which have stimulating effects on rat smooth muscles and further studies should focus on its mechanism of action. <br>
Links
Where it is published
- DOI doi.org/10.17034/32862614.v1 ↗
DOI / persistent id · from zivahub uct ac za
Catalogue records · 1
- OAI-PMH record api.figshare.com/v2/oai?verb=GetRecord&metadataPrefix=oai_dc&identifier=oai%3Af… ↗
metadata API · from zivahub uct ac za
Topics
Provenance · 3 source records, 7 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| ZivaHub | oai:figshare.com:article/32862614 | 12 d ago | JSON v1 |
| Deakin Research Online | oai:figshare.com:article/32862614 | 12 d ago | JSON v1 |
| DMU Figshare | oai:figshare.com:article/32862614 | 12 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| concepts[field].local:field:earth-environmental | mapping · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | |
| concepts[field].local:field:earth-environmental | mapping · figshare dmu ac uk | connector:figshare_dmu_ac_uk@1.0.0 | |
| concepts[field].local:field:earth-environmental | mapping · dro deakin edu au | connector:dro_deakin_edu_au@1.0.0 | |
| description | source · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | /metadata/dc/description |
| license_text | source · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | |
| publication_date | source · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | |
| title | source · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | /metadata/dc/title |