Data · dataset · 2026
Transdermal delivery of pramipexole using microneedle technology for the potential treatment of Parkinson’s disease
Listed in ZivaHub and Deakin Research Online and DMU Figshare — shown once because both records carry DOI 10.17034/32639478.v1
Parkinson's disease is a debilitating neurodegenerative disease primarily impacting neurones responsible for dopamine production within the brain.
Description
Pramipexole (PRA) is a dopamine agonist that enhances dopamine neurotransmission, restoring balance and alleviating symptoms. The work presented here shows how transdermal drug delivery, using microneedle (MN) technology, is a promising avenue for addresing issues with current oral treatment of PRA.
In vivo investigations confirmed the successful delivery of PRA from dissolving MNs (Cmax = 511.00 ng/mL, Tmax = 4 hrs) and hydrogel-forming MNs (Cmax = 328.30 ng/mL, Tmax = 24 hrs). Notably, both types of MNs sustained PRA plasma levels over a 5-day period compared to 48 hrs following oral administration
Links
Where it is published
- DOI doi.org/10.17034/32639478.v1 ↗
DOI / persistent id · from zivahub uct ac za
Catalogue records · 1
- OAI-PMH record api.figshare.com/v2/oai?verb=GetRecord&metadataPrefix=oai_dc&identifier=oai%3Af… ↗
metadata API · from zivahub uct ac za
Topics
- From keywords
- Earth & Environmental Science · Earth & Environmental Science · Earth & Environmental Science · Medicine & Health · Medicine & Health · Medicine & Health
- Inferred from text
- Disease 75%
Provenance · 3 source records, 11 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| ZivaHub | oai:figshare.com:article/32639478 | 9 d ago | JSON v1 |
| Deakin Research Online | oai:figshare.com:article/32639478 | 9 d ago | JSON v1 |
| DMU Figshare | oai:figshare.com:article/32639478 | 9 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| concepts[disease].local:disease:disease | enrichment · zivahub uct ac za | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[field].local:field:earth-environmental | mapping · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | |
| concepts[field].local:field:earth-environmental | mapping · figshare dmu ac uk | connector:figshare_dmu_ac_uk@1.0.0 | |
| concepts[field].local:field:earth-environmental | mapping · dro deakin edu au | connector:dro_deakin_edu_au@1.0.0 | |
| concepts[field].local:field:medicine-health | mapping · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | |
| concepts[field].local:field:medicine-health | mapping · dro deakin edu au | connector:dro_deakin_edu_au@1.0.0 | |
| concepts[field].local:field:medicine-health | mapping · figshare dmu ac uk | connector:figshare_dmu_ac_uk@1.0.0 | |
| description | source · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | /metadata/dc/description |
| license_text | source · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | |
| publication_date | source · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | |
| title | source · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | /metadata/dc/title |