Data Sheet 1_Integrated pathogen detection and immune profiling in posner-schlossman syndrome: a metagenomic and cytokine approach.csv

Baseline clinical features were comparable between CMV subgroups. Six pro-inflammatory cytokines were significantly higher in PSS patients than controls, whereas no cytokine differed between CMV subgroups after Bonferroni correction. All seven models poorly discriminated CMV status; quadratic discriminant analysis yielded the maximum AUC of merely 0.552.

SHAP values verified weak predictive power of cytokines, and learning curves indicated severe overfitting and limited generalizability within the evaluated range of training sample sizes.</p>Conclusion<p>Within the current sample size and measured cytokine panel, no statistically significant or stable difference in aqueous cytokine profiles was detected between CMV-positive and CMV-negative PSS patients, even with advanced machine learning methods.

Our findings are consistent with the inflammation amplifier hypothesis, but the current cross-sectional data cannot definitively confirm CMV’s biological role, nor rule out CMV as a primary pathogenic trigger in a subset of PSS cases. Direct pathogen detection is required for personalized antiviral treatment, and shared inflammatory pathways provide universal targets for novel immunomodulatory therapies for all PSS patients.</p>