Data Sheet 1_Association of temporal and masseter muscle thickness with cognitive function and clinical severity in Alzheimer’s disease: a retrospective study.pdf

Spearman’s correlation analysis revealed that both TMT and MMT were correlated with the Mini-Mental State Examination (MMSE) and CDR. After adjusting for various confounding factors using ordered logistic regression and multiple linear regression, TMT was found to be independently associated with AD severity (OR: 0.424, 95% CI: 0.290–0.618, p < 0.001) and positively correlated with MMSE scores. MMT showed only a weak independent association with CDR staging (OR: 0.830, 95% CI: 0.724–0.952, p = 0.008), while no significant correlation was observed with the MMSE.

Stratified analysis revealed that the TMT maintained a consistent association in both male and female patients, whereas the MMT achieved statistical significance only in females in ordered logistic regression; all other findings were not statistically significant.</p>Conclusion<p>Temporal muscle thickness is associated with cognitive impairment and clinical severity in patients with AD and may serve as a simple, noninvasive imaging marker; in contrast, the independent associations of MMT with disease severity were weak and sex-specific, suggesting that its clinical utility may be limited and requires further validation.</p>