Multi-dimensional dataset of components, activity, and metabolites of Sparganii Rhizoma before and after compatibility with Natrii Sulfas

"Yaxiao (Natrii Sulfas) is difficult to combine with Jing Sanleng (Sparganii Rhizoma)" is one of the contraindications known as the "Nineteen Incompatibilities." In this study, HPLC was used to determine the contents of 12 organic acids and aldehydes in Sparganii Rhizoma before and after compatibility with Natrii Sulfas at different ratios. A blood stasis rat model was used to evaluate the antithrombotic effects of Sparganii Rhizoma before and after compatibility with Natrii Sulfas.

Untargeted metabolomics was employed to detect serum metabolites in rats before and after the compatibility of Sparganii Rhizoma with Natrii Sulfas, and orthogonal partial least squares discriminant analysis (OPLS-DA) was used to screen differential metabolites. This dataset comprises multi-dimensional data on changes in chemical component contents, pharmacological activity, and metabolites before and after the compatibility of Sparganii Rhizoma with Natrii Sulfas, providing data support for further elucidation of the scientific connotation of the compatibility contraindication between Natrii Sulfas and Sparganii Rhizoma and for rational and effective clinical medication.