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Data · dataset · 2018

Replication Data for: Reliability and validity of the World Health Organization reading standards for paediatric chest radiographs used in the field in an impact study of Pneumococcal Conjugate Vaccine in Kilifi, Kenya

Listed in LSHTM Data Compass

Radiologically-confirmed pneumonia (RCP) is a specific end-point used in trials of Pneumococcal Conjugate Vaccine (PCV) to estimate vaccine efficacy.

Description

The dataset is for a study which was set up to ascertain repeatability and reliability of paediatric chest radiographs(CXR) interpretation using percent agreement and Cohen’s kappa in a study of the impact of PCV on pneumonia. The study was conducted in Kilifi County Hospital(KCH) between April 2006 and March 2014.

All children aged ≥2 months to <12 years who were admitted to KCH and residents of Kilifi Health and Demographic Surveillance System (KHDSS) were eligible for the study. Radiographs were obtained from 2,716 children admitted with clinically defined severe or very-severe pneumonia. The images were randomly grouped into batches of approximately 100 images each.

Read the rest (2 more)

To assess repeatability, a 5% random sample was presented twice. All the images were read once by two local primary readers. Discordant readings and 13% of concordant readings were arbitrated by a panel of three expert radiologists.

The images were read between January 2013 and October 2014. The findings were that Intra- and inter-observer agreements on interpretations of RCP are moderately good to high. Good sensitivity and high specificity make RCP, determined in the field, a suitable endpoint to evaluate vaccine effectiveness.

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Catalogue records · 1

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Provenance · 1 source records, 9 field assertions
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