Data · dataset · 2026
Causal relationships between pathogen-derived antibodies and major neurological disorders: A Mendelian randomization study
Listed in ScienceDB
The role of infections in the etiology of brain disorders is increasingly recognized, yet causal relationships remain largely unresolved.
Description
Here, we perform a comprehensive Generalized Summary-data-based Mendelian Randomization (GSMR) analysis to systematically investigate the causal associations of genetically predicted antibody responses to 46 diverse pathogens with 13 major brain diseases. Our study reveals several novel and paradoxical causal links.
We find strong genetic evidence for a protective effect of Herpes Simplex Virus 1 (HSV-1) seropositivity against Attention-Deficit/Hyperactivity Disorder (ADHD) and a protective association between Chlamydia trachomatis seropositivity and anxiety disorders. Furthermore, we uncover a dual role for Epstein-Barr virus (EBV) in multiple sclerosis (MS), where antibodies against the lytic-phase protein ZEBRA are protective, contrasting the established risk from EBNA-1 antibodies.
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These findings demonstrate that the nature of the host immune response, rather than infection status alone, is a critical determinant of brain health outcomes. This genetic atlas of pathogen-brain interactions challenges the conventional view of infections as purely detrimental and opens new avenues for developing immunomodulatory strategies for a range of brain disorders.
Links
Where it is published
- DOI doi.org/10.57760/sciencedb.32549 ↗
DOI / persistent id · from scidb cn
Catalogue records · 1
- OAI-PMH record scidb.cn/oai?verb=GetRecord&metadataPrefix=oai_dc&identifier=10.57760%2… ↗
metadata API · from scidb cn
Topics
- From keywords
- Earth & Environmental Science · Engineering · Humanities · Life Sciences · Social Science
- Inferred from text
- Genetics 71%
Provenance · 1 source records, 11 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| ScienceDB | 10.57760/sciencedb.32549 | 11 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · scidb cn | connector:scidb_cn@1.0.0 | |
| concepts[field].anzsrc:group:3105 | enrichment · scidb cn | taxonomy-embedding@1.0.0 | title+keywords+description (71%) |
| concepts[field].local:field:earth-environmental | mapping · scidb cn | connector:scidb_cn@1.0.0 | |
| concepts[field].local:field:engineering | mapping · scidb cn | connector:scidb_cn@1.0.0 | |
| concepts[field].local:field:humanities | mapping · scidb cn | connector:scidb_cn@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · scidb cn | connector:scidb_cn@1.0.0 | |
| concepts[field].local:field:social-science | mapping · scidb cn | connector:scidb_cn@1.0.0 | |
| description | source · scidb cn | connector:scidb_cn@1.0.0 | /metadata/dc/description |
| license | source · scidb cn | connector:scidb_cn@1.0.0 | /metadata/dc/rights |
| publication_date | source · scidb cn | connector:scidb_cn@1.0.0 | |
| title | source · scidb cn | connector:scidb_cn@1.0.0 | /metadata/dc/title |