Development of biodegradable implants for sustained drug delivery

Polymeric coatings were developed which prolonged the release from these implants and increased their potential as a drug delivery device for chronic conditions. Sterilisation is an important factor which must be considered when designing a new implantable device. Gamma radiation, microwave radiation and ultraviolet light were investigated as potential sterilisation methods for polymeric implants.

Microwave radiation proved to be an ineffective sterilisation method. However, gamma radiation and ultraviolet light showed promise. Matrix-type implants containing levothyroxine sodium were fabricated using solvent casting and demonstrated promising in vitro release rates for the treatment of hypothyroidism (a common condition which can have debilitating side effects and result in high costs to the health service or patient if not managed effectively).

The implants produced in this work have the potential to improve the treatment outcomes and quality of life of patients with hypothyroidism. The simple implantable devices produced in this thesis are easily prepared and have the potential to be applied to a wide range of drug compounds and clinical conditions. This simplicity also gives them potential to be used in the on demand production of personalised drug delivery devices.