Investigating the effects of anti-pseudomonal agents

<p>This dataset presents the investigating of the effects of six primary anti-pseudomonal antibiotics, namely amikacin, cefepime, ciprofloxacin, meropenem, piperacillin and tazobactam, on the planktonic growth of, and formation of biofilm by three different strains of the resilient respiratory pathogen, <em>Pseudomonas aeruginosa</em> [two drug-sensitive strains: the wild-type reference strain, PAO1(WT), and a clinical isolate (DS), as well as a multidrug resistant (MDR) clinically isolated variant of the pathogen].</p> <p>These agents were investigated individually and in combination with the macrolide antibiotic, clarithromycin.

Although all three test strains of <em>P. aeruginosa</em> are resistant to clarithromycin, this agent was included as an adjunct to the conventional anti-pseudomonal agents because of its inhibitory effects on various virulence factors of the pathogen. Following acquisition of the minimal inhibitory concentrations (MICs) of the individual anti-pseudomonal agents with respect to planktonic growth of, and biofilm formation by all three strains of <em>P. aeruginosa</em>, these experiments were repeated using the test anti-pseudomonal antibiotics in combination with clarithromycin.