Table · dataset · 2026
Supplementary file 1_A multifunctional Fe3O4@Au-HPG-Glc theranostic platform for MRI/fluorescence-guided photothermal ablation of osteosarcoma.docx
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Background<p>The clinical management of osteosarcoma is challenged by its aggressive growth and deep anatomical location.
Description
Photothermal therapy offers a minimally invasive approach through localized thermal ablation, but its effectiveness is constrained by poor tissue penetration and inaccurate targeting of deep tumors without real-time guidance.</p>Methods<p>We synthesized flower-like Fe<sub>3</sub>O<sub>4</sub>@Au nanoparticles coated with hyperbranched polyglycerol (HPG) and conjugated with glucose (Glc) (Fe<sub>3</sub>O<sub>4</sub>@Au-HPG-Glc).
In an osteosarcoma mouse model, the photothermal efficacy of the nanoprobes was evaluated by comparing two groups: the control group receiving phosphate-buffered saline plus laser irradiation (phosphate-buffered saline (PBS) + Laser) and the treatment group receiving Fe<sub>3</sub>O<sub>4</sub>@Au-HPG-Glc nanoprobes plus laser irradiation (NPs + Laser). Intratumoral temperature was monitored by infrared thermography, with longitudinal tracking of tumor volume and body weight.
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Major organs were examined by H&E staining. Tumor accumulation was assessed via whole-body fluorescence and T<sub>2</sub>-weighted magnetic resonance imaging (MRI); pharmacokinetics and biodistribution were quantified by inductively coupled plasma mass spectrometry (ICP-MS).</p>Results<p>The NPs + Laser regimen produced rapid intratumoral heating during the 0–4 min irradiation window and significantly delayed tumor growth compared with the PBS + Laser control group, with stable body weight and no overt organ lesions on H&E staining.
Whole-body fluorescence and T<sub>2</sub>-weighted MRI confirmed tumor-site accumulation of the nanoprobes. ICP-MS-based pharmacokinetic and biodistribution analyses provided quantitative exposure context, including systemic clearance, reticuloendothelial system capture, and measurable tumor uptake. Together, these data facilitated interpretation of the subsequent photothermal response.</p>Discussion<p>Flower-like Fe<sub>3</sub>O<sub>4</sub>@Au-HPG-Glc enables image-guided photothermal treatment in an osteosarcoma model, supported by quantitative pharmacokinetic and biodistribution measurements and an acceptable short-course safety profile.
This work establishes a clear imaging-exposure-response relationship and provides a strong foundation for further optimization of magnetic-optical combination strategies in precision cancer therapy.</p>
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- DOI doi.org/10.3389/fbioe.2026.1868939.s001 ↗
DOI / persistent id · from figshare com
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- OAI-PMH record api.figshare.com/v2/oai?verb=GetRecord&metadataPrefix=oai_dc&identifier=oai%3Af… ↗
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Topics
- From keywords
- Astronomy & Astrophysics · Chemistry · Computer Science & AI · Earth & Environmental Science · Economics & Finance · Engineering · Humanities · Life Sciences · Medicine & Health · Ocean & Atmospheric Science · Social Science
- Inferred from text
- Biomedical engineering 69% · Cancer 75% · Imaging 75% · Longitudinal study 65% · Magnetic resonance imaging 75% · Mass spectrometry 75%
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