Semiautomated Synthesis and Interactive Visualization of Zeolitic Imidazolate Framework-Based Biocomposites

However, their preparation is highly sensitive to precursor composition, concentration, washing conditions, and operator-dependent handling procedures. Here, we combine a semiautomated syringe-pump system, high-throughput sample preparation, and digital data visualization to map synthesis–structure–property relationships in ZIF biocomposites.

A programmable four-syringe pump platform was used to systematically prepare 360 distinct samples in triplicate, yielding 1080 samples. The investigated synthetic parameters were relative amounts of metal, ligand, protein, the total precursor concentration, and the washing protocol. Structural, chemical, and functional characterization yielded a data set of ∼2250 entries comprising crystalline-to-amorphous ratios, IR-based protein-to-framework ratios, encapsulation efficiency, and loading capacity.