Table 2_Correlation between myocardial radiomics features at the left atrium–left atrial appendage junction and stroke risk in atrial fibrillation patients: a retrospective case–control study.docx

Least Absolute Shrinkage and Selection Operator (LASSO) regression was used to screen features, and a logistic regression model combining radiomics features and clinical parameters was constructed. Group comparisons were performed using t-tests or Mann–Whitney U tests. The predictive ability of the model was evaluated with the receiver operating characteristic (ROC) curve, and a nomogram was used for risk assessment.</p>Results<p>Compared with AF patients without stroke, patients with AF-related cardioembolic stroke significantly increased myocardial thickness at the LA–LAA junction [7.1 (6.43–8.33) mm vs. 6.58 ± 1.45 mm, p < 0.05].

In addition, multivariate logistic regression demonstrated that myocardial thickness was independently associated with AF-related cardioembolic stroke. Three radiomics features were selected by LASSO regression in AF-related cardioembolic stroke and non-AF-non-stroke patients, and a radiomics score (Rad-score) was generated. The Rad-score was statistically significant between the groups (p < 0.001).

The combined model incorporating Rad-score and clinical parameters achieved an area under curve (AUC) of 0.968 in the test cohort.</p>Conclusion<p>Both myocardial radiomics features and myocardial thickness at the LA–LAA junction may serve as potential imaging markers associated with AF-related cardioembolic stroke. Their incremental value for stroke risk stratification beyond established clinical risk factors requires further validation in larger prospective cohorts.</p>