Table · dataset · 2026
Virucidal activity and differential antiviral efficacy of curcuminoid preparations against porcine epidemic diarrhea virus and feline infectious peritonitis virus
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<p>Curcuminoids from <i>Curcuma longa</i> L. have exhibited antiviral activity against several human viruses; however, their comparative efficacy against animal coronaviruses remains unclear.
Description
This study evaluated the antiviral and virucidal effects of curcumin (CUR), demethoxycurcumin (DMC), bisdemethoxycurcumin (BDMC), a curcuminoid-rich extract (CRE), and its solid dispersion (CRE-SD) against porcine epidemic diarrhoea virus (PEDV) and feline infectious peritonitis virus (FIPV).
Against PEDV, all compounds exhibited multi-stage antiviral activity, confirmed by cytopathic effect reduction, IPMA, and RT-qPCR. DMC was the most consistently potent (EC<sub>50</sub> = 0.48–0.98 µg/mL), followed by BDMC and CUR (0.37–4.47, and 1.50–1.99 µg/mL, respectively), while only BDMC lacked prophylactic activity. Purified curcuminoids showed limited activity against FIPV, though this virus remained susceptible to the extract formulations.
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Molecular docking supported the experimental findings. Notably, CRE and CRE-SD exerted strong virucidal activity against both viruses, suggesting synergistic effects of multiple constituents. These findings highlight curcuminoid formulations as promising veterinary antivirals and disinfectants.</p>
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- DOI doi.org/10.6084/m9.figshare.33945833.v1 ↗
DOI / persistent id · from figshare com
Catalogue records · 1
- OAI-PMH record api.figshare.com/v2/oai?verb=GetRecord&metadataPrefix=oai_dc&identifier=oai%3Af… ↗
metadata API · from figshare com
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Provenance · 1 source records, 21 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| figshare | oai:figshare.com:article/33945833 | 10 d ago | JSON v1 |
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| concepts[field].anzsrc:field:320211 | mapping · figshare com | vocabulary-mapper@1.0.0 | keywords['Infectious Diseases'] |
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| concepts[field].local:field:psychology-behavioral | mapping · figshare com | connector:figshare_com@1.0.0 | |
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| title | source · figshare com | connector:figshare_com@1.0.0 | /metadata/dc/title |