Table 1_Case report: Butylphthalide-associated severe thrombocytopenia, a rare adverse drug reaction.docx

Although generally well-tolerated, severe thrombocytopenia as a rare adverse reaction has not been fully recognized. Herein, we report a severe case of probable DL-NBP-associated thrombocytopenia to increase clinical awareness and inform clinical management.</p>Case Presentation<p>A 69-year-old male with hypertension was admitted for acute brainstem infarction.

His hospitalization was complicated by catastrophic thrombocytopenia (min 1.0 × 10⁹/L), suggestive of a possible immune-mediated thrombocytopenia. Subsequent complications included hypoxemia, pneumonia, occult gastrointestinal blood loss, and muscular venous thrombosis of the right calf, creating complex management challenges. Through multidisciplinary collaboration, multimodal tailored treatment was delivered to balance the risks of stroke recurrence and bleeding: corticosteroids, platelet transfusion, recombinant human thrombopoietin and recombinant human interleukin-11 were administered for presumed immune-mediated thrombocytopenia, and antiplatelet therapy was sequentially modified.