<p>Model challenge and recovery compared to experimental data.</p>

<p>The 100 neuron heterogeneous population here simulates 2 days of basal activity, followed by 5 days of dehydration, and 15 days of recovery, compared against experimental data from <a href="ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.1014832#pcbi.1014832.g001" target="_blank">Fig 1</a>. Two input signal protocols are compared, a default linear ramp (black) and a non-linear ramp (red) with a more rapid initial increase in osmotic signal.

Within the variability of the experimental data both ramps are potentially consistent. The linear ramp varies from the store data in its slower initial decline in content, more closely matched by the non-linear ramp, which produces a faster increase in secretion than synthesis, resulting in more rapid initial store depletion. However, in the plasma signal this results in a drop off in response, as the more active neurons become fully depleted.